Publications by authors named "Adam D Hines"
Article Synopsis
- General anesthetics, like propofol and isoflurane, disrupt brain activity by enhancing inhibition and blocking neurotransmitter release at certain synapses.
- Research focused on how isoflurane affects different neurotransmitter systems showed that it mainly impaired the release of neurotransmitters at excitatory cholinergic synapses.
- In contrast, isoflurane had minimal impact on inhibitory GABAergic and glutamatergic synapses, indicating a selective inhibitory effect in the brain during general anesthesia.
Article Synopsis
- Super-resolution microscopy allows researchers to study the nanoscale organization of proteins in living tissues, but it's often limited to cells grown in isolation.
- The authors developed a method to track the movement of the protein syntaxin1A (Sx1a) in adult fly brains, revealing that Sx1a becomes more mobile after neural stimulation.
- They investigated the effects of different anesthetics on Sx1a dynamics, finding that some anesthetics like propofol and isoflurane reduce protein mobility, while others like ketamine have minimal impact.
Article Synopsis
- * The study tested ICA-105574, a small molecule activator of Kv11.1, which effectively restored function in mutant channels associated with cLQTS2 in lab models.
- * While ICA-105574 corrected prolonged cardiac repolarization in a model with the A422T mutation, higher doses unexpectedly caused early repolarization, indicating a potential risk for overcorrection in treatment strategies.
