Publications by authors named "Adam D Fearnow"
Cancer Res Commun
September 2024
Article Synopsis
- CAR T cells are effective against leukemias but struggle with persistence due to the short-lived nature of effector T cells; thus, enhancing CAR T-cell memory is crucial for long-lasting immune protection.
- IL7 receptor (IL7R) signaling is essential for memory T cells, but prolonged exposure to IL7 decreases IL7R surface expression.
- Researchers engineered T cells to either secrete IL7 or express a specific IL7Rα-chimeric cytokine receptor (CCR), ensuring persistent signaling and functionality when combined with a cytotoxic CAR, leading to improved tumor-targeted therapy outcomes.
