Publications by authors named "Adam C Diehl"

Article Synopsis
  • KRAS variant alleles can influence the biological behavior of pancreatic ductal adenocarcinomas (PDA), affecting patient prognosis and treatment options.
  • A study at the University of Washington analyzed advanced PDA patients, revealing that specific KRAS mutations, particularly G12R, were linked to better overall and progression-free survival compared to other variants.
  • However, having PI3K pathway mutations alongside KRAS G12R diminished this survival advantage, suggesting that the KRAS/PI3K genomic profile can help predict treatment responses in PDA patients.
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Purpose: With the relentless expansion of genetics into every field of medicine, stronger preclinical and clinical medical student education in genetics is needed. The explosion of genetic information cannot be addressed by simply adding content hours. We proposed that students be provided a tool to access accurate clinical information on genetic conditions and, through this tool, build life-long learning habits to carry them through their medical careers.

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Synopsis of recent research by authors named "Adam C Diehl"

  • - Adam C. Diehl's research focuses on the genetic underpinnings of pancreatic ductal adenocarcinomas (PDA), specifically exploring the impact of KRAS mutation variants and concurrent PI3K pathway alterations on patient survival outcomes.
  • - His study, published in "Oncologist," utilized retrospective data from patients at the University of Washington, demonstrating that different KRAS mutations can significantly influence prognostic factors and treatment options in advanced PDA cases.
  • - Additionally, Diehl addresses the integration of genetic education within medical curricula, advocating for a systematic approach to teaching clinical genetics to enhance medical student learning and prepare future physicians for the growing relevance of genetics in medicine, as outlined in his article in "Genet Med."