Same-day discharge robot-assisted laparoscopic prostatectomy: feasibility, safety and patient experience.

Objectives: To report a single centre's experience of the feasibility, safety and patient acceptability of same-day discharge robot-assisted laparoscopic prostatectomy (RALP).

Subjects/patients And Methods: Between June 2015 and December 2021, a total of 180 pre-selected consecutive patients underwent RALP with the intention to discharge on the same day as surgery. Cases were performed by two surgeons.

PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis.

Aberrant phosphoinositide 3-kinase (PI3K), mitogen-activated protein kinase (MAPK) and WNT signalling are emerging as key events in the multistep nature of prostate tumourigenesis and progression. Here, we report a compound prostate cancer murine model in which these signalling pathways cooperate to produce a more aggressive prostate cancer phenotype. Using Cre-LoxP technology and the probasin promoter, we combined the loss of Pten (Pten ), to activate the PI3K signalling pathway, with either dominant stabilized β-catenin [Catnb ] or activated K-RAS (K-Ras ) to aberrantly activate WNT and MAPK signalling, respectively.

Radial scar lesions of the breast diagnosed by needle core biopsy: analysis of cases containing occult malignancy.

Aim: To identify and review cases of false negative needle core biopsy (NCB) in the preoperative investigation of radial scar/complex sclerosing lesion (RS/CSL) lesions - that is, benign NCB from RS/CSL which contained malignancy on excision.

Methods And Results: A total of 11 false negative NCB in RS/CSL lesions from 281 (3.9%) were identified (6 cases: B1, 2 cases: B2 and 3 cases: B3).