Tensile Stresses in the Coating with Interlayer under Normal and Tangential Loading.

In this paper, we obtained the analytic solution of the three-dimensional problem of elasticity concerning non-homogeneous half-space, in which the surface is under normal and tangential loading applied in a circular area. Half-space is composed of the homogeneous body, as well as coatings containing two homogeneous layers: interlayer and top layer. The analysis was carried out in cases where the Young's modulus of the intermediate layer differed from the Young's modulus of the substrate and the top layer.

The appropriate use of non-steroidal anti-inflammatory drugs in rheumatic disease: opinions of a multidisciplinary European expert panel.

Introduction: Given the safety issues of non-steroidal anti-inflammatory drugs (NSAID) and the robustness of guidelines, making treatment choices in daily clinical practice is increasingly difficult. This study aimed systematically to analyse the opinions of a multidisciplinary European expert panel on the appropriateness of different NSAID, with or without the use of a proton pump inhibitor (PPI), in individual patients with chronic rheumatic disease.

Methods: /Using the Research and Development/University of California at Los Angeles appropriateness method, the appropriateness of five (non-)selective NSAID with or without a PPI was assessed for 144 hypothetical patient profiles, ie, unique combinations of cardiovascular and gastrointestinal risk factors.