Publications by authors named "Adam Baca"
Article Synopsis
- Mice fed a diet low in n-3 fatty acids and high in n-6 fatty acids gained significantly more weight over three generations compared to those on a standard diet.
- This dietary change led to increased adipogenesis and a notable upregulation of stearyl-coenzyme A desaturase 1 (Scd1), which is linked to higher plasma triglyceride levels.
- Additionally, the low n-3 fatty acid diet decreased beneficial fatty acids in the liver while increasing harmful ones like arachidonic acid, resulting in obesity and negative effects on organ health such as liver steatosis and hypertrophy of the heart and kidneys.
Docosahexaenoic acid (DHA), a crucial nervous system n-3 PUFA, may be obtained in the diet or synthesized in vivo from dietary alpha-linolenic acid (LNA). We addressed whether DHA synthesis is regulated by the availability of dietary DHA in artificially reared rat pups, during p8 to p28 development. Over 20 days, one group of rat pups was continuously fed deuterium-labeled LNA (d5-LNA) and no other n-3 PUFA (d5-LNA diet), and a second group of rat pups was fed a d5-LNA diet with unlabeled DHA (d5-LNA + DHA diet).
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