Rate of and risks for regression of cervical intraepithelial neoplasia 2 in adolescents and young women.

Objective: To describe the natural history of cervical intraepithelial neoplasia (CIN) 2 in a prospective study of adolescents and young women, and to examine the behavioral and biologic factors associated with regression and progression.

Methods: Adolescents and women aged 13 to 24 years who were referred for abnormal cytology and were found to have CIN 2 on histology were evaluated at 4-month intervals. Risks for regression were defined as three consecutive negative cytology and histology visits, and progression to CIN 3 was estimated using Cox proportional hazards regression models.

Risks for cervical intraepithelial neoplasia 3 among adolescents and young women with abnormal cytology.

Objective: To estimate the risks of cervical intraepithelial neoplasia (CIN) 3 among girls and women aged 13 to 24 years who were referred for abnormal cytology while receiving care in a large health maintenance organization.

Methods: At the time of referral, patients had a colposcopic examination and biopsy if needed. Histology was sent to a centralized laboratory.