Synthesis and Fungicidal Activities of Coumarin Derivatives as Succinate Dehydrogenase Inhibitors.

Succinate dehydrogenase inhibitors (SDHIs) have been developed to the fastest growing family of fungicides. To develop novel succinate dehydrogenase (SDH) inhibitors, 27 novel non-amides coumarin derivatives were designed, synthesized, and characterized. The bioassay revealed that most of the target compounds exhibited significant antifungal activity against Botrytis cinerea in vitro.