Impact of the COVID-19 pandemic on acute otolaryngology inpatient activity at a tertiary referral centre: A retrospective analysis.

Objective: To determine the impact of the COVID-19 pandemic on acute admissions and inpatient activity at a tertiary referral centre.

Design: Retrospective review of coding-based inpatient electronic records.

Setting: An otolaryngology and head and neck surgery department at a major UK trauma and tertiary referral centre.

Importance of the immune system in head and neck cancer.

Head and neck squamous cell carcinoma (HNSCC) are a heterogeneous group of tumors, mainly caused by exposure to cigarette smoke and/or alcohol. In recent years, a virally driven subset of cancers driven by human papillomavirus subtype 16 [HPV-16]) has emerged. Our own data and data from other groups have demonstrated the favorable clinical outcome of HPV-driven oropharyngeal tumors and in both HPV+ and HPV- cancers the importance of a high density of tumor-associated lymphocytes for survival.

Impact of social deprivation on the outcome of major head and neck cancer surgery in England: A national analysis.

Background: Socioeconomic status plays an important role in the incidence and prognosis of many cancers. We examined the relationship between social deprivation and clinical outcomes in patients undergoing major surgery for head and neck cancer.

Methods: A retrospective population-based observational study was performed.

Head and Neck Squamous Cell Carcinomas Are Characterized by a Stable Immune Signature Within the Primary Tumor Over Time and Space.

Genetic and morphologic heterogeneity is well-documented in solid cancers. Immune cells are also variably distributed within the tumor; this heterogeneity is difficult to assess in small biopsies, and may confound our understanding of the determinants of successful immunotherapy. We examined the transcriptomic variability of the immunologic signature in head and neck squamous cell carcinoma (HNSCC) within individual tumors using transcriptomic and IHC assessments.

Timing of neck dissection in association with transoral surgery: A systematic review.

Background: The purpose of this study was to present our evaluation of the importance of timing (early vs synchronous vs delayed) in conjunction with transoral laser surgery for head and neck squamous cell carcinoma (HNSCC).

Methods: Articles addressing surgical management via transoral laser surgery for HNSCC were included for review.

Results: Twenty-six articles fulfilled our criteria.