Publications by authors named "Adaeze C Echezona"
Article Synopsis
- Retinoblastoma is the most common eye cancer in children and poses treatment challenges, especially in developing countries due to late diagnoses.
- Current treatments include surgery, radiotherapy, and chemotherapy, but their side effects can lead to high mortality rates and reduced quality of life.
- Nanoparticle delivery systems show promise in improving cancer treatment by targeting therapy more effectively, yet their application in clinical settings for retinoblastoma remains underexplored.
Diseases affecting the anterior segment of the eye are the primary causes of vision impairment and blindness globally. Drug administration through the topical ocular route is widely accepted because of its user/patient friendliness - ease of administration and convenience. However, it remains a significant challenge to efficiently deliver drugs to the eye through this route because of various structural and physiological constraints that restrict the distribution of therapeutic molecules into the ocular tissues.
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- * Preventive measures, such as social distancing and mask-wearing, have helped slow the virus's spread; however, the persistent nature of the virus and its variants makes complete eradication difficult.
- * The development of effective vaccines relies heavily on nanotechnology, which enhances vaccine delivery and efficacy; currently, four vaccines are approved for use, with more in progress.
Improved antimalarial activity of caprol-based nanostructured lipid carriers encapsulating artemether-lumefantrine for oral administration.
Afr Health Sci
December 2020
Background: Artemether and lumefantrine display low aqueous solubility leading to poor release profile; hence the need for the use of lipid-based systems to improve their oral bioavailability so as to improve their therapeutic efficacy.
Aim And Objective: The objective of this work was to utilize potentials of nanostructured lipid carriers (NLCs) for improvement of the oral bioavailability of artemether and lumefantrine combination and to evaluate its efficacy in the treatment of malaria. This study reports a method of formulation, characterization and evaluation of the therapeutic efficacies of caprol-based NLC delivery systems with artemether and lumefantrine.
Anterior eye segment disorders are treated with eye drops and ointments, which have low ocular bioavailability necessitating the need for improved alternatives. Lipid microsuspension of gentamicin sulphate was developed for the treatment of susceptible eye diseases. Lipid microsuspensions encapsulating gentamicin sulphate were produced by hot homogenization and evaluated.
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- Alzheimer's Disease (AD) is the leading cause of dementia, influenced by genetics, environmental factors, and lifestyle choices, with early detection and drug management essential for better outcomes.
- Numerous interventions are explored, including various therapeutic agents, gene therapy, and adherence to specific diets like the Mediterranean and MIND diets, alongside the potential use of medicinal plants.
- Advances in nanotechnology are being investigated for creating novel drug formulations and using Superparamagnetic Iron Oxide Nanoparticles (SPIONs) for early AD detection.