Publications by authors named "Ada da Silva Matos"
Article Synopsis
- Plasmodium vivax causes millions of malaria cases worldwide, highlighting the urgent need for effective vaccine development, especially given the lack of studies on specific vaccine candidates for this species.
- The merozoite protein CyRPA has shown promise as a vaccine candidate due to its essential role in the growth and invasion of P. falciparum, and preliminary studies suggest that PvCyRPA is better at providing protection compared to traditional malaria vaccine candidates.
- Research in Brazilian malaria-endemic areas indicates that PvCyRPA is immunogenic, eliciting a strong immune response with important B and T cell epitopes, supporting its potential inclusion in future malaria vaccine formulations targeting P. vivax
Dynamics of IgM and IgG Antibody Response Profile against Linear B-Cell Epitopes from Exoerythrocytic (CelTOS and TRAP) and Erythrocytic (CyRPA) Phases of : Follow-Up Study.
Antibodies (Basel)
August 2024
Malaria is a serious health problem worldwide affecting mainly children and socially vulnerable people. The biological particularities of , such as the ability to generate dormant liver stages, the rapid maturation of gametocytes, and the emergence of drug resistance, have contributed to difficulties in disease control. In this context, developing an effective vaccine has been considered a fundamental tool for the efficient control and/or elimination of vivax malaria.
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- A study focused on malaria in the Americas highlights the need for a multi-antigen vaccine due to the complex life cycle of the malaria parasite.
- Researchers developed a chimeric recombinant protein called PvRMC-1, which was found to elicit immune responses in mice when formulated with different adjuvants.
- Results showed that while all formulations generated immune responses, Stimune and AddaVax were more effective in promoting both cellular and humoral immunity compared to aluminum hydroxide, suggesting that PvRMC-1 could be a strong candidate for further vaccine development.
The PvCelTOS, PvCyRPA, and Pvs25 proteins play important roles during the three stages of the lifecycle. In this study, we designed and expressed a recombinant modular chimeric protein (PvRMC-1) composed of the main antigenic regions of these vaccine candidates. After structure modelling by prediction, the chimeric protein was expressed, and the antigenicity was assessed by IgM and IgG (total and subclass) ELISA in 301 naturally exposed individuals from the Brazilian Amazon.
View Article and Find Full Text PDFRecombinant Plasmodium vivax circumsporozoite surface protein allelic variants: antibody recognition by individuals from three communities in the Brazilian Amazon.
Sci Rep
August 2020
Circumsporozoite protein (CSP) variants of P. vivax, besides having variations in the protein repetitive portion, can differ from each other in aspects such as geographical distribution, intensity of transmission, vectorial competence and immune response. Such aspects must be considered to P.
View Article and Find Full Text PDFThrombospondin-related adhesive protein (TRAP) is essential for sporozoite motility and the invasion of mosquitoes' salivary gland and vertebrate's hepatocyte and is, thus, considered a promising pre-erythrocytic vaccine candidate. Despite the existence of a few reports on naturally acquired immune response against TRAP (PvTRAP), it has never been explored so far in the Amazon region, so results are conflicting. Here, we characterized the (IgG and IgG subclass) antibody reactivity against recombinant PvTRAP in a cross-sectional study of 299 individuals exposed to malaria infection in three municipalities (Cruzeiro do Sul, Mâncio Lima and Guajará) from the Acre state of the Brazilian Amazon.
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