The Advantages of Next-Generation Sequencing Molecular Classification in Endometrial Cancer Diagnosis.

Endometrial cancer (EC) is the most frequent gynecological cancer. The ESGO/ESTRO/ESP 2020 guidelines identify prognostic groups based on morpho-molecular characteristics. This study aims to evaluate the clinical applicability of NGS analysis to define an appropriate risk class and to improve the diagnostic and prognostic stratification of ECs.

Monogalactosyldiacylglycerol anti-inflammatory activity on adult articular cartilage.

The mono- and the digalactosyldiacylglycerol (MGDG and DGDG) galactolipids with a high content of polyunsaturated fatty acids, mainly omega-3, have been purified from the thermophilic blue-green alga ETS-05 that colonises the therapeutic thermal mud of Abano and Montegrotto, Italy. The therapeutic thermal mud is applied mostly to osteoarthritic cartilage patients. In the present study, a possible anti-inflammatory function of MGDG in cartilage has been studied in the avian articular cartilage model.

Expression of serum amyloid A in chondrocytes and myoblasts differentiation and inflammation: possible role in cholesterol homeostasis.

Serum amyloid A (SAA) is synthesized by the liver during the acute phase. Local expression of SAA mRNA has been reported also in non-liver cells, a potential local source of SAA protein not related to the systemic acute phase response. SAA function has not been established yet.