Publications by authors named "Ada L Ramirez-Sanchez"
Arthritis Rheumatol
June 2023
Article Synopsis
- This study investigates how genetic variants in the STAT4 gene impact its expression in CD4+ T cells, which are crucial for immune responses, particularly in systemic lupus erythematosus (SLE).
- Healthy donors with the risk allele for STAT4 (R/R genotype) show persistent high levels of STAT4 and increased inflammatory responses compared to those with the non-risk allele (NR/NR) after stimulation with interleukin-12 (IL-12).
- Results suggest that the R/R genotype is linked to worse clinical outcomes in lupus nephritis patients, indicating that targeting the IL-12/STAT4 pathway could improve treatment for these patients.
