Causes of infant and under-five (under-5) morbidity and mortality among hospitalized patients in Southern Nigeria: A hospital based study.

Background: Rate and pattern of under-five mortality is a reflection of a society's healthcare system and quality of life. This study is aimed at reviewing the causes of infants and under-five morbidity and mortality in Calabar, Southern Nigeria.

Methods: This study used retrospective descriptive cross-sectional design.

Haematinic and Hepatoprotective Properties of Fruit Mesocarp on Phenylhydrazine-Induced Anaemia in Experimental Rats.

The level and potential of iron contained in fluted pumpkin () has been exploited as a blood tonic; however, the potentials of some other parts of the plant are unknown. The effect of fruit mesocarp (aqueous extract) on phenylhydrazine (PHZ)-induced anaemia in experimental rats was investigated in a bid to determine its curative properties and potential in reversing haemolytic anaemia and protection of liver health. The LD of the fruit extract was determined using Lorke's method for the determination of acute toxicity.

Antimicrobial analysis of honey against Staphylococcus aureus isolates from wound, ADMET properties of its bioactive compounds and in-silico evaluation against dihydropteroate synthase.

Background: One of the main challenges of wound healing is infection with multi-drug resistant (MDR) bacteria such as Staphylococcus aureus. The spectrum of antibiotics used to treat them is declining; thus, there is a need for alternatives. Our study was designed to evaluate the antimicrobial properties of honey, its pharmacokinetics (ADMET) properties and in-silico analysis of its bioactive compounds against dihydropteroate synthase of S.

A Blind Test of Computational Technique for Predicting the Likelihood of Peptide Sequences to Cyclize.

An in silico computational technique for predicting peptide sequences that can be cyclized by cyanobactin macrocyclases, e.g., PatG, is reported.

The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain.

Peptide macrocycles are found in many biologically active natural products. Their versatility, resistance to proteolysis and ability to traverse membranes has made them desirable molecules. Although technologies exist to synthesize such compounds, the full extent of diversity found among natural macrocycles has yet to be achieved synthetically.