Chinese-Australian carers' perceived needs and preferences in planning to embed an iSupport for Dementia program in aged care services.

Objective: To assess Chinese-Australian carers' needs and preferences through co-design strategies with stakeholders to embed an evidence-based iSupport for Dementia program into routine community aged care services in Chinese ethno-specific aged care organisations.

Methods: A cross-sectional survey was conducted from July to August 2022 in three Chinese ethno-specific aged care organisations in Australia. We applied a univariate analysis to test variables associated with carers' needs and preferences when embedding the iSupport for Dementia program into routine practice among community aged care services.

Maternal immune activation alters placental histone-3 lysine-9 tri-methylation, offspring sensorimotor processing, and hypothalamic transposable element expression in a sex-specific manner.

Animal models of maternal immune activation (MIA) are central to identifying the biological mechanisms that underly the association between prenatal infection and neuropsychiatric disorder susceptibility. Many studies, however, have limited their scope to protein coding genes and their role in mediating this inherent risk, while much less attention has been directed towards exploring the roles of the epigenome and transposable elements (TEs). In Experiment 1, we demonstrate the ability of MIA to alter the chromatin landscape of the placenta.

Color vision deficits in intermediate age-related macular degeneration.

Purpose: To assess the effect of intermediate age-related macular degeneration (AMD) on foveal cone-contrast thresholds.

Methods: We measured L-M and S-cone-contrast thresholds in subjects with intermediate AMD (n = 10) and age-matched control subjects (n = 10). Monocular, foveal 3-degree Gaussian blobs (600-millisecond raised cosine) were presented at 16 cone ratios throughout L-, M-, and S-cone space, and threshold contours were modeled with probability summation between two independent detection mechanisms.

Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae.

Current approaches for identifying synergistic targets use cell culture models to see if the combined effect of clinically available drugs is better than predicted by their individual efficacy. New techniques are needed to systematically and rationally identify targets and pathways that may be synergistic targets. Here, we created a tool to screen and identify molecular targets that may synergize with new inhibitors of target of rapamycin (TOR), a conserved protein that is a major integrator of cell proliferation signals in the nutrient-signaling pathway.

Changes in bone density and geometry of the upper extremities after stroke: a case report.

Purpose: The purpose of this study was to examine changes in bone density and geometry of the forearm region and motor function of the paretic upper extremity in a person with subacute stroke. Client Description: The participant was a 48-year-old man with right hemiparesis.

Intervention: Not applicable.

Future research on dementia relating to culturally and linguistically diverse communities.

About one in five older Australians were born overseas. However, there has been very little information published in Australia or internationally about dementia in persons from culturally and linguistically diverse (CALD) backgrounds. This limits our ability to plan for and provide evidence-based medical care, social care and aged care services to persons from CALD backgrounds.