PAV-05 Naphthoquinone Potently Inhibit Zika Virus Replication in Infected Cells.

Background: Zika (ZIKV) is a virus transmitted by mosquitoes that can cause Guillain- Barré syndrome and congenital malformations like microcephaly. Given its explosive resurgence and the resulting epidemics in 2016, the search for effective antiviral drugs has become absolutely necessary.

Methods: In this study, we examined the potential of naphthoquinone derivatives that have a sulfonamide or sulfonate group to inhibit ZIKV replication in primary cultured neurons and in Vero cells.

Development of a patient decision aid for people with refractory angina: protocol for a three-phase pilot study.

Background: Refractory angina is a severe chronic disease, defined as angina which cannot be controlled by usual treatments for heart disease. This disease is frightening, debilitating, and difficult to manage. Many people suffering refractory have inadequate pain relief, continually revisit emergency departments for help, undergo repeated cardiac investigations, and struggle with obtaining appropriate care.

[Let us care with plays?].

Given the importance of play in the everyday life of hospitalized children, the purpose of the study was to identify the perception of the nursing team in the preparation of children and adolescents for hospital procedures at university hospital in Aracaju. We used exploratory search with a qualitative approach with the nursing staff of the pediatric unit. It is that professionals do not perform the techniques with the plays in their daily activities, but know the importance of this resource.

Characteristics of masticatory muscles in children with unilateral posterior crossbite.

The aim of this study was to detect possible differences in the EMG (electromyography) activity, chewing rate (CR), cycle duration (CD) and preferred chewing side (PCS) between children with and without unilateral posterior crossbite. Thirty-seven children aged from 7 to 10 years were selected from the clinic of the Department of Pediatric Dentistry, Piracicaba Dental School, Brazil, and divided into two groups: unilateral posterior crossbite (UPCB group, n = 17), and normal occlusion (NOccl group, n = 20). The PCS was determined using a visual spot-checking method.

Posterior crossbite and functional changes. A systematic review.

Objective: To assess, by systematically reviewing the literature, the functional changes of the masticatory muscles associated with posterior crossbite in the primary and mixed dentition.

Materials And Methods: A literature survey from the Medline database covering the period from January 1965 to February 2008 was performed. Randomized controlled trials, controlled clinical trials, and clinical trials that evaluated bite force, surface electromyography, and signs and symptoms of temporomandibular disorders (TMD) were included.

Natriuretic peptides: putting the evidence into practice.

With advances in cardiovascular medicine, people are living longer with cardiovascular disease. There is an increased incidence and prevalence of heart failure. Misdiagnosis of heart failure, particularly in the early stages, is not uncommon.

Ultrasonography and electromyography of masticatory muscles in a group of adolescents with signs and symptoms of TMD.

The thickness and electrical activity of masseter and anterior temporalis muscles were compared in adolescents with and without signs and symptoms of TMD. Forty individuals were selected using the Cranio Mandibular Index and a questionnaire. There was no significant correlation between thickness and activity (p > 0.

Nociception- and anxiety-like behavior in rats submitted to different periods of restraint stress.

The aim of this study was to evaluate the effect of acute, sub-chronic and chronic stress on nociception induced by formalin injection in rats' temporomandibular joint (TMJ). It was evaluated the relation between blood levels of adrenocorticotropin, corticosterone, the levels of anxiety and nociceptive responses recorded after different stress protocols. Animals were initially submitted to acute restraint stress (15; 30 min and 1 h), or exposed to sub-chronic (3 days-1 h/day) or chronic stress (40 days-1 h/day).

The effects of restraint stress on nociceptive responses induced by formalin injected in rat's TMJ.

It has been reported that stress can alter nociception from superficial tissues, such as skin and subcutaneous region. However, the influence of stress on an experimental deep nociception model is not understood. In this study, the temporomandibular joint (TMJ) formalin test was used to evaluate the effects of acute and chronic restraint stress on nociceptive responses in rats.