Publications by authors named "Achyuta Ramesh"
Diabetologia
September 2024
Article Synopsis
- Diabetic kidney disease (DKD) is a major cause of chronic kidney issues, and the understanding of its mechanisms in humans has lagged behind animal studies, impacting treatment development.
- The researchers employed a Spatial TissuE Proteomics (STEP) pipeline to analyze 21 proteins across various kidney tissue samples from healthy individuals and those with different stages of DKD, revealing specific patterns in protein expression and cellular composition.
- The study found significant changes in inflammatory cell presence and protein loss in the kidneys as DKD progressed, highlighting the utility of the STEP pipeline in understanding the disease's pathophysiology.
