Publications by authors named "Achmad Zainuddin"

Article Synopsis
  • * People are increasingly choosing natural preservatives over synthetic ones for health reasons, with specific natural options gaining popularity in Asia.
  • * The paper reviews research since 2000 on certain natural compounds, highlighting their antioxidant, antimicrobial, and preservative properties in food.
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The effects of alkali type and pH on the physical properties of carrageenan have been extensively studied. However, their effects on certain characteristics of solid-state properties of carrageenan have not been identified. This research aimed to investigate the effect of alkaline solvent type and pH on the solid physical properties of carrageenan isolated from .

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Aim: The SARS-CoV-2 virus is a disease that has mild to severe effects on patients, which can even lead to death. One of the enzymes that act as DNA replication is the main protease, which becomes the main target in the inhibition of the SARS-CoV-2 virus. In finding effective drugs against this virus, is a potential herbal plant because it has been tested to have high phytochemical content and bioactivity.

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Introduction: Uncontrolled biofilm can cause several diseases such as dental caries, gingivitis, and periodontitis. Dental caries is a disease caused by the accumulation of plaque-containing pathogenic bacteria, including . These bacteria infect the root canals of teeth and colonize to form biofilms.

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Coronavirus disease-2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus-2 attacking the lungs, which contain the most oxygen. The involvement of oxidative stress in the body and the role of antioxidant compounds, namely catechins, are thought to be able to prevent various diseases, including the COVID-19 infection virus. An approach was employed between the catechins and the protein NADPH oxidase (Nox), followed by the coronavirus protease protein, to limit the generation of reactive oxygen species.

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Background: COVID-19 (Coronavirus Disease 2019) caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) has infected millions of people and caused hundreds of thousands of deaths worldwide. However, until now no specific drug for SARS-CoV-2 infection has been found. This prompted many researchers to explore compounds as anti-SARS-CoV-2 candidates.

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A new promising fluorescent chemosensor based on a 2-hydroxynaphthaldehyde skeleton was successfully synthesized through double imine formation as a yellow solid with an overall chemical yield of 63%. The compound showed UV/Visible maxima of at 394 nm in DMSO. Based on spectroscopic data of FTIR, ToF-HRMS, H-NMR, and C-NMR, the product was characterized as 1-(()-(()-(3,5-dichloro-2-hydroxybenzilydine)hydrazono)methyl)naphthalene-2-ol.

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Recently, the antioxidant is applied for the teeth bleaching treatment as an alternative of toxic material of hydrogen peroxide that is used in teeth bleaching. One of natural sources antioxidant is those containing active antioxidant agents. To be applied as a new bioactive constituent in teeth bleaching treatment, a preexperimental study is performed.

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The utilization of medicinal plants has long been explored for the discovery of antibacterial agents and the most effective mechanisms or new targets that can prevent and control the spread of antibiotic resistance. One kind of bacterial cell wall inhibition is the inactivation of the MurA enzyme that contributes to the formation of peptidoglycan. Another approach is to interfere with the cell-cell communication of bacteria called the Quorum sensing (QS) system.

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High-density polyethylene (HDPE) is among the flexible polymers on account of its appropriate processability and adequate mechanical properties. Grafting reactive monomers such as glycidyl methacrylate (GMA) and maleic anhydride (MAH) onto polyethylene was one of the ultimate choices to improve the physicochemical properties of HDPE. MAH is an appropriate option for grafting onto HDPE owing to its low reactivity and it relatively undergoes a direct grafting onto the polymer.

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A new synthetic analog of bufadienolide, methyl isobryophyllinate A (1), and a known synthetic analog, methyl isobersaldegenate-1,3,5-orthoacetate (2), were obtained by methanolysis of bryophyllin A (3) and bersaldegenin-1,3,5-orthoacetate (5) in basic solution. Structure-insecticidal activity relationship studies revealed both orthoacetate and alpha-pyrone moieties seemed to be essential structural elements for exhibiting insecticidal activity, whereas oxygenated substituents in the C ring enhanced the insecticidal activity against the third instar larvae of silkworm (Bombyx mori).

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