Impact of smoking on frequency and spectrum of and mutations in treatment naive Indonesian lung cancer patients.

Indonesia has the highest cigarette consumption in the world. We explored the clinical impact of smoking on the prevalence of and mutations and survival in this prospective study. 143 treatment naive lung cancer patients were recruited from Persahabatan Hospital, a national tertiary hospital.

Correlation between Domestic Cigarette Smoke Exposure and Respiratory Complaints, Hospitalization and School Absence due to Respiratory Complains in the Indonesian Elementary School-Aged Children.

Background: Over 43 million Indonesian children who are exposed to cigarette smoke are at risk of having health hazard and morbidities.

Aims: The aim of this study is to identify the correlation between cigarette smoke exposure and respiratory complaints, hospitalization, as well as school absence due to respiratory complaints in elementary school-aged Indonesian children.

Materials And Methods: A cross-sectional study was conducted in nonsmoking elementary school-aged children.

Efficacy of gefitinib and radiotherapy combination in Indonesian patients with lung adenocarcinoma.

Introduction: Combinations of gefitinib and radiotherapy have been observed to have synergistic and anti-proliferative effects on lung cancer in vitro. In the clinical setting, patients who presented with respiratory difficulties such as superior vena cava syndrome (SVCS), radiotherapy should be given immediately to address the emergency while waiting for the results of epidermal growth factor receptor (EGFR) mutation test. However, there has been no study that described the role of radio-therapy in Indonesian patients with EGFR-mutant lung adenocarcinoma.

Urinary Cotinine Level in Indonesian Children Exposed to Domestic Cigarette Smoke.

Background: Cotinine is a major metabolite of nicotine, and its urinary level is an indicator of exposure to cigarette smoke. The present study was aimed at identifying the urinary cotinine level in Indonesian children who were exposed and not exposed to domestic cigarette smoke.

Methods: The study was a cross-sectional study in elementary school-aged children who had not smoked.

EGFR mutation prevalence in Asia-Pacific and Russian patients with advanced NSCLC of adenocarcinoma and non-adenocarcinoma histology: The IGNITE study.

Objectives: Limited understanding exists of epidermal growth factor receptor (EGFR) mutation frequency in less common subgroups of advanced non-small-cell lung cancer (aNSCLC) (e.g. squamous cell carcinoma [SCC]), and to what extent local practices exclude patients from EGFR testing based on their clinical characteristics.

Circulating Tumor Cell and Cell-free Circulating Tumor DNA in Lung Cancer.

Circulating tumor cells (CTCs) are tumor cells that are separated from the primary site or metastatic lesion and disseminate in blood circulation. CTCs are considered to be part of the long process of cancer metastasis. As a 'liquid biopsy', CTC molecular examination and investigation of single cancer cells create an important opportunity for providing an understanding of cancer biology and the process of metastasis.