Therapeutic potential of Indonesian plant extracts in combating malaria and protozoan neglected tropical disease.

Background: Neglected tropical diseases (NTDs) afflict nearly 2 billion people worldwide and are caused by various pathogens, such as bacteria, protozoa, and trypanosoma, prevalent in tropical and subtropical regions. Among the 17 NTDs recognized by the World Health Organization (WHO), protozoal infections caused by Plasmodium, Entamoeba, Leishmania, and Trypanosoma are particularly prominent and pose significant public health. Indonesia, endowed with a rich biodiversity owing to its tropical climate, harbors numerous plant species with potent biological activities that hold promise for therapeutic interventions.

Three new dihydrochalcones from the leaves of Jarrett and their activity against .

Three new dihydrochalcones: artoserichalcone A-C (), were isolated from the leaves of . The structures of compounds were determined based on NMR spectrum (H, C, and 2D) and HRESIMS spectroscopic analysis. Compounds () and () showed active antimalarial activity with IC values of 16.

: A promising plant for isolating anti-hepatitis C virus agents.

Medicinal plants are potential resources for isolating drug candidates. Various plants have been reported to possess pharmacological effects including anti-hepatitis C activities. The current study examined the anti-hepatitis C virus (HCV) activities of extracts in solvents with various polarities and further evaluated the mechanism of action of the extracts using Western blotting and combination treatment models.

Promising alkaloids and flavonoids compounds as anti-hepatitis c virus agents: a review.

Background: Virus infections are presently seen as a major public health problem. Hepatitis C Virus (HCV) is recognized as a "silent killer" because the acute infection has no symptoms, and it develops as a chronic infection that causes hepatocellular carcinoma and liver damage. The World Health Organization (WHO) predicts that between 130-170 million people are estimated to have chronic Hepatitis C.

An in vitro study of an Artocarpus heterophyllus substance as a hepatitis C antiviral and its combination with current anti-HCV drugs.

Background: Current therapy of chronic hepatitis C virus (HCV) with direct-acting antivirals (DAAs) has dramatically improved the sustained virologic response (SVR) of affected patients; however, treatment with DAAs remains expensive, and drug-resistant HCV variants remain a threat. As a result, there is still a need to continue to develop affordable and effective drugs for the treatment of HCV. Previously, we have demonstrated that a crude extract from Artocarpus heterophyllus leaves is a potential anti-HCV candidate.

stem bark exhibited antimalarial activity by Lactate Dehydrogenase (LDH) assay.

Objectives: The antimalarial drug resistance is an obstacle in the effort to overcome malaria. The new alternative antimalarial drug became in great attention of urgent need. Current antimalarial drugs were derived from plants.

stem bark contains antimalarial substances against .

Objectives: The finding of alternative medicine for malarial treatment still has become a substantial demand. The plant is one of the potential sources of drugs, among other natural sources. Artocarpus species showed great potential as the antimalarial source.

antimalarial activity of Miq. Stem extracts and fractions on lactate dehydrogenase (LDH) assay.

Objectives: The rapid spread of antimalarial drug resistance is becoming a problem in the treatment of malaria. The fact was indicated the importance of finding new antimalarial drugs. The genus Garcinia is well known to be a rich source of bioactive prenylated xanthones and triterpenes reported for their antimalarial activity.

Safety evaluation of an antimalarial herbal product from (AS201-01) in healthy volunteers.

Objectives: tablets (AS201-01) have previously been shown to have potent bioactivity as an antimalarial and to produce no unwanted side effects in animal models. Here, we present the phase 1 clinical trial conducted to evaluate the safety of AS201-01 tablets in healthy volunteers.

Methods: The study was a randomized, double-blind controlled cross-over, a placebo-controlled design consisting of a 4-day treatment of AS201-01 tablets.

Analgesic and Antipyretic Activities of Ethyl Acetate Fraction Tablet of in Animal Models.

Objectives: To determine the analgesic and antipyretic activities of a tablet derived from ethyl acetate fraction (AS201-01) in animal models.

Methods: The tablet derived from AS201-01 contains an equivalent of 35 mg andrographolide per tablet. Analgesic activity was determined using an acetic acid-induced writhing test on adult male mice.

A tablet derived from complements dihydroartemisinin-piperaquine treatment of malaria in pregnant mice.

Objectives: The use of standard antimalarial drugs, such as dihydroartemisinin-piperaquine (DHP) for the treatment of malaria during pregnancy is limited due to the risk of teratogenicity. The alternative is therefore required although few exist. Here we show a phytopharmaceutical drug derived from (AS201-01), which is effective as herbal antimalarial both and and may be a suitable alternative when used in complementary treatment with DHP.

Alkaloid and benzopyran compounds of Melicope latifolia fruit exhibit anti-hepatitis C virus activities.

Background: New agents for developing alternative or complementary medicine to treat the hepatitis C virus (HCV) are still needed due to high rates of HCV infection globally and the current limitations of available treatments. Treatment of HCV with a combination of direct acting antivirals have been shown to be approximately 90% effective but will be limited in the future due to the emergence of drug resistance and high cost. The leaves of Melicope latifolia have previously been reported to have anti-HCV activity and are a potential source of bioactive compounds for future novel drug development.

Bioanalytical method development and validation for quantification of morachalcone A in rabbit plasma using high performance liquid chromatography.

Artocarpus champeden (A. champeden) ethanol extract has been reported as antimalarial activity and prospective to be developed as phytomedicine products. The active marker compound was identical with known prenylated chalcone compound, Morachalcone A.

Antiplasmodial Activity of Isolated Polyphenols from Leaves Against 3D7 .

Background: was selected from a screening program devoted to search naturally occurring antimalarial compound from plants in Alas Purwo National Park, Banyuwangi, East Java, Indonesia. The previous studies showed that ethanol extract of leaves contains some polyphenol compounds.

Objective: This study was designed to isolate and investigate antiplasmodial activity of polyphenol compounds.