Publications by authors named "Achmad A P Kartamihardja"
Article Synopsis
- Gadolinium deposition in the brain, especially in iron-rich areas, has raised concerns about its effects on neuronal cells, specifically focusing on Purkinje cells in the cerebellum.
- The study examined how iron (Fe) influenced the impact of gadolinium-based contrast agents (GBCA) on the growth of dendrites in Purkinje cells using various treatment groups and immunocytochemistry techniques.
- Results indicated that while the number of Purkinje cells remained similar across all groups, dendrite growth was significantly enhanced in groups treated with gadolinium compared to controls, with iron amplifying the gadopentetate effect but not influencing gadobutrol.
Article Synopsis
- - The study investigates the ability of water hyacinth to absorb gadolinium (Gd), which has not been thoroughly researched despite the plant’s known effectiveness at removing heavy metals.
- - After growing water hyacinth in Gd-containing solutions for 30 days, results showed a 98.5% absorption of GdCl by the roots, with minimal transfer to the leaves, while only 12% of gadoterate (GBCA) was absorbed.
- - The findings suggest that water hyacinth can effectively remove Gd ions from water without harming the plant, but it does not absorb GBCA, potentially leading to environmental risks as Gd accumulates in aquatic ecosystems.
Objective: To investigate the role of transporter proteins in gadolinium (Gd) distribution and retention in the brain after one high-dose injection of Gd-based contrast agent (GBCA).
Methods And Materials: 30 ddY mice were randomly divided into three treatment groups to be intravenously injected with either Gadodiamide (linear GBCA), Gadobutrol (macrocyclic GBCA), or Gadoterate (macrocyclic GBCA) at a dose of 5 mmol/kg, while five mice in the control group received 250 µL saline. Five minutes (5 min) and ten days (10d) post-injection, the cerebrospinal fluid (CSF), choroid plexus (CP), and meninges and associated vasculature (MAV) were collected.