Publications by authors named "Achitpol Thongkam"
Article Synopsis
- - The study analyzed 81 reports from 29 countries to evaluate the prevalence and risk factors of COVID-19-associated candidemia (CAC), finding a global prevalence of 4.33% in ICU patients, with higher rates in high-income countries.
- - Resistant Candida species accounted for 2% of CAC cases, and the mortality rate among affected ICU patients was alarmingly high at 68.40%.
- - Identified risk factors for CAC included antibiotic use, central venous catheters, and mechanical ventilation, presenting opportunities for intervention to reduce CAC risk.
Background: Pythiosis is a rare disease with high mortality, with over 94% of cases reported from Thailand and India. Prompt diagnosis and surgery improves patient outcomes. Therefore, continuing professional development (CPD) is essential for early recognition.
View Article and Find Full Text PDFImmunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination is diminished in hematopoietic stem cell transplant (HSCT) recipients. To summarize current evidence and identify risk factors for attenuated responses, 5 electronic databases were searched since database inceptions through 12 January 2023 for studies reporting humoral and/or cellular immunogenicity of SARS-CoV-2 vaccination in the HSCT population. Using descriptive statistics and random-effects models, extracted numbers of responders and pooled odds ratios (pORs) with 95% confidence intervals (CIs) for risk factors of negative immune responses were analyzed (PROSPERO: CRD42021277109).
View Article and Find Full Text PDFBackground: Infectious diseases and ophthalmology professional societies have disagreed regarding ocular screening in patients with candidemia. We aimed to summarize the current evidence on the prevalence of ocular candidiasis (OC) and Candida endophthalmitis (CE) according to the standardized definitions.
Methods: A literature search was conducted from the inception date through 16 October 2022 using PubMed, Embase, and SCOPUS.
Patients with multiple myeloma (MM) have a diminished immune response to coronavirus disease 2019 (COVID-19) vaccines. Risk factors for an impaired immune response are yet to be determined. We aimed to summarize the COVID-19 vaccine immunogenicity and to identify factors that influence the humoral immune response in patients with MM.
View Article and Find Full Text PDFImmunogenicity and Risk Factors Associated With Poor Humoral Immune Response of SARS-CoV-2 Vaccines in Recipients of Solid Organ Transplant: A Systematic Review and Meta-Analysis.
JAMA Netw Open
April 2022
Article Synopsis
- This study examines how solid organ transplant (SOT) recipients respond to COVID-19 vaccinations, noting that they have reduced immune responses compared to the general population.!* -
- Researchers reviewed a total of 83 studies and found that after multiple doses of mRNA vaccines, only 63.1% of SOT recipients developed a positive humoral immune response, indicating significant variability in effectiveness.!* -
- Factors like older age were linked to poorer antibody responses, but some individuals who initially didn’t respond had an improvement after receiving a fourth vaccine dose.!*
Background: In allogeneic haematopoietic stem cell transplant (allo-HSCT) recipients, the inter-relationship between post-transplant cytomegalovirus (CMV) and subsequent invasive fungal infections (IFIs) is conflicting and the association of CMV serostatus with IFIs has not been evaluated.
Objectives: To determine the relationship between CMV infection/serostatus and IFIs in allo-HSCT populations.
Data Sources: A systematic literature search was conducted from existence until 11 July 2021 using Medline, Embase and ISI Web of Science databases.
Background: Cytomegalovirus (CMV) and invasive aspergillosis (IA) cause high morbidity and mortality in solid organ transplant (SOT) recipients. There are conflicting data with respect to the impact of CMV on IA development in SOT recipients.
Methods: A literature search was conducted from existence through to 2 April 2021 using MEDLINE, Embase, and ISI Web of Science databases.
Vascular pythiosis is a rare, neglected, life-threatening disease with mortality of 100% in patients with incomplete surgical resection or patients with persistently elevated serum β-d-glucan (BDG). The study was conducted to understand the clinical outcomes of new treatment protocols and potential use of erythrocyte sedimentation rate (ESR) and c-reactive protein (CRP) as alternative monitoring tools, given recent favorable minimum inhibitory concentrations (MICs) of antibacterial agents and prohibitive cost of serum BDG in Thailand. A prospective cohort study of patients with vascular pythiosis was conducted between February 2019 and August 2020.
View Article and Find Full Text PDFBackground: Increased rates of resistance and its morbidity and mortality have raised concern about the strategy of antibiotic use.
Objectives: This study aimed to determine the prevalence of methicillin-resistant (MRSA) and vancomycin-resistant (VRSA) isolates among Thai patients with infection and to identify risk factors and appropriate antibiotics for these resistant strains.
Methods: Data of culture-proven isolates from clinical specimens during 2017 in King Chulalongkorn Memorial Hospital, Thailand, were retrospectively collected and classified as methicillin-sensitive or MRSA by cefoxitin screening and oxacillin minimum inhibitory concentration by the Vitek 2 system.