The principle of 'brain energy on demand' and its predictive power for stress, sleep, stroke, obesity and diabetes.

Does the brain actively draw energy from the body when needed? There are different schools of thought regarding energy metabolism. In this study, the various theoretical models are classified into one of two categories: (1) conceptualizations of the brain as being purely passively supplied, which we call 'P-models,' and (2) models understanding the brain as not only passively receiving energy but also actively procuring energy for itself on demand, which we call 'A-models.' One prominent example of such theories making use of an A-model is the selfish-brain theory.

Obesity and Type 2 Diabetes Mellitus Explained by the Free Energy Principle.

According to the free energy principle, all sentient beings strive to minimize surprise or, in other words, an information-theoretical quantity called variational free energy. Consequently, psychosocial "stress" can be redefined as a state of "heightened expected free energy," that is, a state of "expected surprise" or "uncertainty." Individuals experiencing stress primarily attempt to reduce uncertainty, or expected free energy, with the help of what is called an uncertainty resolution program (URP).

How Stress Can Change Our Deepest Preferences: Stress Habituation Explained Using the Free Energy Principle.

People who habituate to stress show a repetition-induced response attenuation-neuroendocrine, cardiovascular, neuroenergetic, and emotional-when exposed to a threatening environment. But the exact dynamics underlying stress habituation remain obscure. The free energy principle offers a unifying account of self-organising systems such as the human brain.

Psychological stress, body shape and cardiovascular events: Results from the Whitehall II study.

Background And Aim: It is known that persistent psychological stress predicts changes in body shape in two different ways: some stressed people lose weight, others gain weight. It is also known that persistent psychological stress predicts adverse health events. But it is unknown what role the body shape plays in this particular network of relationships.

Brain Mass (Energy) Resistant to Hyperglycaemic Oversupply: A Systematic Review.

Cerebral energy supply is determined by the energy content of the blood. Accordingly, the brain is undersupplied during hypoglycaemia. Whether or not there is an additional cerebral energy demand that depends upon the energy content of the brain is considered differently in two opposing theoretical approaches.

Collective-Mode Enhanced Matter-Wave Optics.

In contrast to light, matter-wave optics of quantum gases deals with interactions even in free space and for ensembles comprising millions of atoms. We exploit these interactions in a quantum degenerate gas as an adjustable lens for coherent atom optics. By combining an interaction-driven quadrupole-mode excitation of a Bose-Einstein condensate (BEC) with a magnetic lens, we form a time-domain matter-wave lens system.

Proximal Disruption of Brain Energy Supply Raises Systemic Blood Glucose: A Systematic Review.

This work joins a series that methodically tests the predictions of the Selfish-Brain theory. The theory postulates a vital ability of the mammalian brain, namely to give priority to its own energy metabolism. The brain behaves "selfishly" in this respect.

Ultracold atom interferometry in space.

Bose-Einstein condensates (BECs) in free fall constitute a promising source for space-borne interferometry. Indeed, BECs enjoy a slowly expanding wave function, display a large spatial coherence and can be engineered and probed by optical techniques. Here we explore matter-wave fringes of multiple spinor components of a BEC released in free fall employing light-pulses to drive Bragg processes and induce phase imprinting on a sounding rocket.

Brain More Resistant to Energy Restriction Than Body: A Systematic Review.

The gluco-lipostatic theory and its modern variants assume that blood glucose and energy stores are controlled in closed-loop feedback processes. The Selfish Brain theory is based on the same assumptions, but additionally postulates that the brain, as an independent energy compartment, self-regulates its energy concentration with the highest priority. In some clinical situations these two theories make opposite predictions.

Cooperation and Social Rules Emerging From the Principle of Surprise Minimization.

The surprise minimization principle has been applied to explain various cognitive processes in humans. Originally describing perceptual and active inference, the framework has been applied to different types of decision making including long-term policies, utility maximization and exploration. This analysis extends the application of surprise minimization (also known as free energy principle) to a multi-agent setup and shows how it can explain the emergence of social rules and cooperation.

Compact and robust diode laser system technology for dual-species ultracold atom experiments with rubidium and potassium in microgravity.

We present a compact and robust distributed-feedback diode laser system architecture for ultracold atom experiments with 41 and 87 in a mobile setup operating at the ZARM drop tower in Bremen. Our system withstands DC accelerations of up to 43 g in operation with only minor adjustments over several drop campaigns. Micro-integrated master-oscillator-power-amplifier modules in conjunction with miniaturized, free-space opto-mechanics are integrated on a platform with a volume of 43 L.

Space-borne Bose-Einstein condensation for precision interferometry.

Owing to the low-gravity conditions in space, space-borne laboratories enable experiments with extended free-fall times. Because Bose-Einstein condensates have an extremely low expansion energy, space-borne atom interferometers based on Bose-Einstein condensation have the potential to have much greater sensitivity to inertial forces than do similar ground-based interferometers. On 23 January 2017, as part of the sounding-rocket mission MAIUS-1, we created Bose-Einstein condensates in space and conducted 110 experiments central to matter-wave interferometry, including laser cooling and trapping of atoms in the presence of the large accelerations experienced during launch.

LTP or LTD? Modeling the Influence of Stress on Synaptic Plasticity.

In cognitive memory, long-term potentiation (LTP) has been shown to occur when presynaptic and postsynaptic activities are highly correlated and glucocorticoid concentrations are in an optimal (i.e., low normal) range.

Effects of blood glucose on delay discounting, food intake and counterregulation in lean and obese men.

Background: Delay discounting as a measure of impulsivity has been shown to be higher in obesity with an association of increased food intake. Moreover, obese humans showed a higher wanting for high-calorie food than lean men when blood glucose concentrations were low. First studies linking blood glucose levels to delay discounting yielded mixed results.

Comparison of symmetric and asymmetric double quantum well extended-cavity diode lasers for broadband passive mode-locking at 780 nm.

We present a compact, mode-locked diode laser system designed to emit a frequency comb in the wavelength range around 780 nm. We compare the mode-locking performance of symmetric and asymmetric double quantum well ridge-waveguide diode laser chips in an extended-cavity diode laser configuration. By reverse biasing a short section of the diode laser chip, passive mode-locking at 3.

Stress-Related Changes in Body Form: Results from the Whitehall II Study.

Objective: Stress is associated with body mass gain in some people but with body mass loss in others. When the stressor persists, some people adapt with their stress responses, whereas others do not. Heart rate variability (HRV) reflects autonomic variability and is related to stress responses to psychosocial challenges.

Uncertainty and stress: Why it causes diseases and how it is mastered by the brain.

The term 'stress' - coined in 1936 - has many definitions, but until now has lacked a theoretical foundation. Here we present an information-theoretic approach - based on the 'free energy principle' - defining the essence of stress; namely, uncertainty. We address three questions: What is uncertainty? What does it do to us? What are our resources to master it? Mathematically speaking, uncertainty is entropy or 'expected surprise'.

Method for in-depth characterization of electro-optic phase modulators.

A flexible method to measure the modulation efficiency and residual amplitude modulation, including non-linearities, of phase modulators is presented. The method is based on demodulation of the modulated optical field in the optical domain by means of a heterodyne interferometer and subsequent analysis of the I&Q quadrature components of the corresponding RF beat note signal. As an example, we determine the phase modulation efficiency and residual amplitude modulation for both the TE and TM modes of a GaAs chip-based phase modulator at the wavelength of 1064 nm.

Development of a compact optical absolute frequency reference for space with 10 instability.

We report on a compact and ruggedized setup for laser frequency stabilization employing Doppler-free spectroscopy of molecular iodine near 532 nm. Using a 30 cm long iodine cell in a triple-pass configuration in combination with noise-canceling detection and residual amplitude modulation control, a frequency instability of 6×10 at 1 s integration time and a Flicker noise floor below 3×10 for integration times between 100 and 1000 s was found. A specific assembly-integration technology was applied for the realization of the spectroscopy setup, ensuring high beam pointing stability and high thermal and mechanical rigidity.

Molecular regulation of urea cycle function by the liver glucocorticoid receptor.

Objective: One of the major side effects of glucocorticoid (GC) treatment is lean tissue wasting, indicating a prominent role in systemic amino acid metabolism. In order to uncover a novel aspect of GCs and their intracellular-receptor, the glucocorticoid receptor (GR), on metabolic control, we conducted amino acid and acylcarnitine profiling in human and mouse models of GC/GR gain- and loss-of-function.

Methods: Blood serum and tissue metabolite levels were determined in Human Addison's disease (AD) patients as well as in mouse models of systemic and liver-specific GR loss-of-function (AAV-miR-GR) with or without dexamethasone (DEX) treatments.

Direct terrestrial test of Lorentz symmetry in electrodynamics to 10(-18).

Lorentz symmetry is a foundational property of modern physics, underlying the standard model of particles and general relativity. It is anticipated that these two theories are low-energy approximations of a single theory that is unified and consistent at the Planck scale. Many unifying proposals allow Lorentz symmetry to be broken, with observable effects appearing at Planck-suppressed levels; thus, precision tests of Lorentz invariance are needed to assess and guide theoretical efforts.

High-power, micro-integrated diode laser modules at 767 and 780 nm for portable quantum gas experiments.

We present micro-integrated diode laser modules operating at wavelengths of 767 and 780 nm for cold quantum gas experiments on potassium and rubidium. The master-oscillator-power-amplifier concept provides both narrow linewidth emission and high optical output power. With a linewidth (10 μs) below 1 MHz and an output power of up to 3 W, these modules are specifically suited for quantum optics experiments and feature the robustness required for operation at a drop tower or on-board a sounding rocket.

Stress habituation, body shape and cardiovascular mortality.

High cardiovascular mortality is well documented in lean phenotypes exhibiting visceral fat accumulation. In contrast, corpulent phenotypes with predominantly subcutaneous fat accumulation display a surprisingly low mortality. The term 'obesity paradox' reflects the difficulty in understanding the biological mechanisms underlying these clinical observations.

Ultra-narrow linewidth DFB-laser with optical feedback from a monolithic confocal Fabry-Perot cavity.

We present a compact, ultra-narrow-linewidth semiconductor laser based on a 780 nm distributed feedback diode laser optically self-locked to a mode of an external monolithic confocal Fabry-Perot resonator. We characterize spectral properties of the laser by measuring its frequency noise power spectral density. The white frequency noise levels at 5 Hz(2)/Hz above a Fourier frequency as small as 20 kHz.