ZraS is a metal sensor integral to ZraPSR, a two-component signaling system found in enterobacters. It belongs to a family of bifunctional sensor histidine kinases (SHKs) and is speculated to sense zinc-induced stress on the bacterial envelope. Information on the structure-function relationship of sensor kinases is elusive due to the lack of full-length structures, intrinsically dynamic behavior, and difficulty trapping them in active state conformations.
View Article and Find Full Text PDFBackground: Rheumatoid arthritis (RA) is an autoimmune disease that affects joints and can have extra-articular manifestations. RA usually tends to be progressive and leads to substantial health care burdens, both in terms of disability and economic costs. Despite the various treatment modalities available, there is still an urgent need for safe and effective medicine based on the pattern of disease presentation.
View Article and Find Full Text PDFIntroduction: Hook plate fixation is a widely used technique for managing lateral clavicle fractures, particularly when the coracoclavicular ligaments are disrupted. However, improper placement of the hook plate can result in rare and challenging complications that require innovative management strategies. This report presents a unique case involving such a complication and describes a minimally invasive, single-stage salvage approach using K-wire fixation to effectively address the issue.
View Article and Find Full Text PDFAliya®Pulsed Electric Field (PEF) technology is an emerging strategy in the field of cancer treatment, offering a novel approach to ablation therapy that does not rely on thermal mechanisms. By employing a multi-stage experimental setup, including potato tuber, porcine liver, and murine breast cancer models, we explored the dose-response relationship on ablation and immune modulation by varying the pulse packets delivered from 20 to 100. The biologic response observed with 60 packets represented a minimum effective dose yielding reproducible ablation parameters, immune response, and efficacy which could be augmented with immune checkpoint blockade.
View Article and Find Full Text PDFThe NLRP3 inflammasome signaling cascade activation is a significant contributor to the initiation and progression of Parkinson's disease (PD). Recent evidence supports that targeting NLRP3 inflammasome assembly could be a potential strategy to halt PD progression. The molecular mechanism of the olfactory-brain axis in mediating PD remains elusive.
View Article and Find Full Text PDFObjective: We examined the impact of a codesigned multicomponent implementation strategy on adherence to evidence-based intrapartum care, respectful maternity care, and newborn care practices in 11 medical schools across two states and a union territory in India.
Methods: We conducted pre-post implementation research using the reach, effectiveness, adoption, implementation, and maintenance (RE-AIM) framework from July 2019 to October 2021. The implementation strategy was codesigned by researchers and medical school faculty.
Objectives: To estimate the levels and trends of maternal and child healthcare (MCH) service utilisation in India across subsidised and unsubsidised health sectors and to explore total market approach to identify geographies where the private sector has potential to improve MCH services in India.
Design And Setting: This study used three recent rounds of the National Family Health Survey (NFHS), a cross-sectional survey in India, conducted in 2005-2006, 2015-2016 and 2019-2021. Bivariate analysis and multinomial logistic regression were used to estimate the utilisation of key MCH indicators from subsidised and unsubsidised health sectors.
Understanding how interacting particles approach thermal equilibrium is a major challenge of quantum simulators. Unlocking the full potential of such systems towards this goal requires flexible initial state preparation, precise time evolution and extensive probes for final state characterization. Here we present a quantum simulator comprising 69 superconducting qubits that supports both universal quantum gates and high-fidelity analogue evolution, with performance beyond the reach of classical simulation in cross-entropy benchmarking experiments.
View Article and Find Full Text PDFBackground: Anal fissure is a common proctologic condition that causes significant pain and anguish to patients, significantly impacting their quality of life and well-being. There are various treatment options for anal fissure, ranging from pharmacological agents that reduce anal sphincter tone to surgical interventions for cases resistant to medical management. Ayurvedic treatments have shown potential for the therapeutic management of anal fissure.
View Article and Find Full Text PDFIntroduction: Diet and lifestyle play pivotal roles in Ayurveda's preventive and therapeutic principles. The rich culinary heritage of Kerala harmoniously aligns with Ayurvedic dietetic principles. With the recent designation of 2023 as the International Year of Millets, there has been a surge of interest in integrating millets into dietary practices worldwide.
View Article and Find Full Text PDFDrug reaction with eosinophilia and systemic symptoms (DRESS) syndrome and haemophagocytic lymphohistiocytosis (HLH) are rare but severe immune-mediated diseases with overlapping clinical manifestations. We present a case of a woman in her late 40s with rheumatoid arthritis who developed DRESS/HLH overlap syndrome after starting hydroxychloroquine and leflunomide therapy. Despite corticosteroid treatment, her condition worsened, necessitating etoposide therapy.
View Article and Find Full Text PDFRespir Med Case Rep
December 2024
Primary pulmonary malignant melanoma is an extremely rare non-epithelial malignancy. Literature is merely limited to a few anecdotal case reports. Herein we present a case of a 74-year-old female who was diagnosed with primary malignant melanoma of the lung.
View Article and Find Full Text PDFThis work deals with the development of a greener RP-HPLC method and chemical pattern recognition for the identification of L. collected from different natural sources and samples traded as '' in Indian herbal drug markets. The simultaneous quantification of α- and β-asarone was performed using 0.
View Article and Find Full Text PDFPurpose: To assess the level of moral distress (MD) and perceptions of ethical climate among pediatric hematology/oncology (PHO) nurses and to identify bioethics topics where increased education was desired.
Methods: In this cross-sectional study, we administered the 26-item Swedish Moral Distress Scale-Revised (sMDS-R), specifically revised and validated for pediatric oncology, in conjunction with the Clinical Ethics Needs Assessment Survey (CENAS). Electronic surveys were sent to inpatient and outpatient PHO nurses.
Early diagnosis and percutaneous closure of symptomatic adult atrial septal defects can enhance cardiac function and relieve symptoms. Thorough pre-procedural evaluation and diligent follow-up care are essential for achieving the best outcomes and ensuring long-term success.
View Article and Find Full Text PDFBackground: Premarital sex in India is hugely stigmatized. With the widespread use of mobile phones and the internet, attitudes and behaviors towards premarital sexual activities are inevitably shifting. This study investigates the impact of digital exposure, specifically mobile phones and the internet on premarital sex and contraception use among unmarried Indian youths.
View Article and Find Full Text PDFAims: The aim of this study is the evaluation of an Azomethine derivative, BCS2, for its antioxidant and anti-tumor activities against mammary carcinoma through the Nrf2- Keap1-HO-1 pathway.
Background: The global prevalence of breast cancer is rising at an alarming rate. The facilitation of abnormal cell proliferation in mammary carcinoma occurs due to the disruption of signaling pathways that balance pro- and antioxidant status, thereby producing oxidative stress that disrupts genomic stability.
: Breast cancer influences more than 2 million women worldwide annually. Since apoptotic dysregulation is a cancer hallmark, targeting apoptotic regulators encompasses strategic drug development for cancer therapy. One such class of apoptotic regulators is inhibitors of apoptosis proteins (IAP) which are a class of E3 ubiquitin ligases that actively function to support cancer growth and survival.
View Article and Find Full Text PDFJ Evid Based Integr Med
January 2025
The study's objective is to conduct a comprehensive systematic review for assessing the safety and efficacy of Ayurvedic interventions in managing hemiplegia/Pakshaghata. The study involved a search across multiple online databases and online clinical trial registries. Additionally, major Ayurveda postgraduate institutes were contacted to acquire unpublished trial data related to hemiplegia/Pakshaghata.
View Article and Find Full Text PDFObjective: This study examined economic inequality in coverage of selected maternal and child healthcare (MCH) indicators in India and its states over the last 15 years.
Design: The study analysed last three rounds of the National Family Health Survey data, conducted during 2005-2006, 2015-2016 and 2019-2021. Bivariate analyses, ratio of richest to poorest, slope index of inequality (SII) and multivariate binary logistic regression analyses were used to examine the coverage as well as inequalities in the outcome indicators for India and its states and at district level.
Quantum error correction (QEC) provides a practical path to fault-tolerant quantum computing through scaling to large qubit numbers, assuming that physical errors are sufficiently uncorrelated in time and space. In superconducting qubit arrays, high-energy impact events can produce correlated errors, violating this key assumption. Following such an event, phonons with energy above the superconducting gap propagate throughout the device substrate, which in turn generate a temporary surge in quasiparticle (QP) density throughout the array.
View Article and Find Full Text PDFIntroduction: Waist circumference (WC) is used as a measure of metabolic syndrome (MeS); neck circumference (NC) can predict MeS. It is simpler to measure and may provide an indication of obstructive sleep apnea (OSA).
Materials And Methods: NC was measured.
Nanocelluloses have garnered significant attention recently in the attempt to create sustainable, improved functional materials. Nanocellulose possesses wide varieties, including rod-shaped crystalline cellulose nanocrystals and elongated cellulose nanofibers, also known as microfibrillated cellulose. In recent times, nanocellulose has sparked research into a wide range of biomedical applications, which vary from developing 3D printed hydrogel to preparing structures with tunable characteristics.
View Article and Find Full Text PDFBone hemorrhage, infection, and large bone defects following surgical treatment of traumatic bone injury have raised potential concerns, underscoring the urgent need to develop multifunctional therapeutic platforms that can effectively address traumatic bone regeneration. Advancements in three-dimensional (3D) printing technology have propelled the development of several engineering disciplines, such as tissue engineering. Nevertheless, 3D-printed frameworks with conventional materials often lack multifunctional capabilities to promote specific activities for diverse regeneration purposes.
View Article and Find Full Text PDFIn present study Wedelolactone (WL) was identified from successive extracts of whole plant (L.) L. using HPTLC, optimised extraction/isolation method and confirmed WL structure.
View Article and Find Full Text PDF