Bovine Respiratory Disease in Veal Calves: Benefits Associated with Its Early Detection by Lung Ultrasonography and Its Prompt Treatment with a Single Dose of a Fixed Combination of Florfenicol and Meloxicam.

Lung ultrasonography can facilitate bovine respiratory disease (BRD) detection and can potentially improve treatment outcomes. In this study, ninety-six veal calves were followed weekly with clinical and lung ultrasound examinations during the production cycle. Thirty-six calves had clinical signs and abnormal lung ultrasound scans (TRT, n = 36) and were promptly treated with florfenicol and meloxicam.

A single subcutaneous dose of eprinomectin (Eprecis) is effective against common gastrointestinal nematodes and lungworms in experimentally infected lactating goats.

Background: The health and productivity of dairy goats continue to be impacted by gastrointestinal nematodes (GIN) and lungworms (LW). Eprinomectin (EPN) is frequently selected for treatment because it is generally effective and does not require a milk withdrawal period. However, some factors, such as lactation, can have an impact on EPN pharmacokinetics and potentially its efficacy.

First report of eprinomectin-resistant isolates of in 5 dairy sheep farms from the in France.

Infection of sheep by gastrointestinal nematodes (GIN) in pastoral systems such as those found in the South Western area of France, the , is one of the main reasons for economic loss and degradation of their welfare. In the present study, the efficacy of eprinomectin (EPN) was monitored on farms from this area following suspicion of lack of anthelmintic efficacy. Suspicions were raised by veterinarians, based on clinical signs ranging from milk and body condition loss, to anaemia, and mortality.

Evaluation of the use of ketoprofen for the treatment of digital dermatitis in dairy cattle: A randomised, positive controlled, clinical trial.

Background: The objective of this study was to evaluate the benefits of administering ketoprofen to cows suffering from active digital dermatitis (DD).

Methods: 158 cows presented with active DD (M1, M2 or M4.1 stage) were randomly allocated to either the control or the treatment group.

QTest: A new way to easily sample, store, and ship samples to perform Q fever PCR analysis on bulk tank milk.

Bulk tank milk (BTM) is an easy, inexpensive, and representative sample for detection of infections (Q fever) in dairy herds using real-time PCR. Bulk tank milk PCR can be performed either for initial herd screening or for monitoring the effectiveness of preventive measures. However, one major limitation under field conditions is the need to deliver BTM samples in adequate condition (quickly, safely, and under refrigeration) to a qualified laboratory.

Effects of calfhood respiratory disease on health and performance of dairy cattle: A systematic review and meta-analysis.

Bovine respiratory disease (BRD) is one of the most common calfhood diseases in dairy cattle. Unfortunately, published data on the short- and long-term effects of calfhood BRD on health and performance are scarce and, when available, often conflicting and uncertain. The objective of this study was therefore to review the scientific literature on the effects of calfhood BRD on health and performance of dairy cattle and summarize the research findings using a meta-analysis approach.

Effect of injectable eprinomectin on milk quality and yield of dairy ewes naturally infected with gastrointestinal nematodes.

The objective was to investigate the effect of injectable eprinomectin on milk yield and quality of dairy ewes naturally infected with gastrointestinal nematodes when grazing in communal pastures. Onehundred and fifty (150) clinically healthy adult lactating ewes, equally selected from 3 farms, were included in the study. On day -7, the ewes on each farm were randomly allocated into 2 equal groups of 25 animals (n=50): Control group (C) and Treated group (T).

Anthelmintic activity of injectable eprinomectin (eprecis 20 mg/mL) in naturally infected dairy sheep.

The anthelmintic activity of an injectable eprinomectin formulation (Eprecis 20 mg/mL) was evaluated in 150 naturally infected dairy sheep raised in 3 semi-intensive flocks. All ewes were at the same stage of lactation and grazed on natural pastures. Ewes did not receive any anthelmintic treatment for at least 4 months prior to the experiment.

Survival associated with cerebrospinal fluid analysis in downer adult dairy cows: A retrospective study (2006-2014).

Background: Threshold values for total nucleated cell count (TNCC) and protein concentration in cerebrospinal fluid (CSF) of downer dairy cows suggestive of a spinal cord lesion were recently published.

Objectives: Determine short- and long-term survival of downer cows that underwent CSF analysis using the reported threshold values. Evaluate the prognostic value of these threshold values to predict short- and long-term survival.

Treatment of experimentally induced bovine respiratory disease in young calves with a single administration of a combination of florfenicol and meloxicam.

This study was designed to evaluate the efficacy of a new florfenicol/meloxicam combination (FMC) in calves with bovine respiratory disease. A total of 90 young calves were challenged via intratracheal deposition of 10 colony-forming units of Data for 84 calves demonstrating a rectal temperature (RT) above 39.5°C and a combined total clinical score (TCS) greater than or equal to 3 were included.

Cerebrospinal Fluid Analysis in Recumbent Adult Dairy Cows With or Without Spinal Cord Lesions.

Background: Diagnosis of central nervous system (CNS) lesions in recumbent dairy cattle (RDC) is challenging because neurologic examination is limited and medical imaging often is challenging or unrewarding. Cerebrospinal fluid (CSF) analysis is useful in the diagnosis of CNS disorders in cattle. However, its utility in identifying spinal cord lesions in RDC remains to be evaluated.

Identification of a Chlamydomonas plastidial 2-lysophosphatidic acid acyltransferase and its use to engineer microalgae with increased oil content.

Despite a strong interest in microalgal oil production, our understanding of the biosynthetic pathways that produce algal lipids and the genes involved in the biosynthetic processes remains incomplete. Here, we report that Chlamydomonas reinhardtii Cre09.g398289 encodes a plastid-targeted 2-lysophosphatidic acid acyltransferase (CrLPAAT1) that acylates the sn-2 position of a 2-lysophosphatidic acid to form phosphatidic acid, the first common precursor of membrane and storage lipids.

Synovitis induced by joint lavage with hypertonic saline solutions in healthy dairy calves.

The objective of this study was to evaluate the effect of a single joint lavage with 7.2% or 15% hypertonic saline solutions (HSS) on the tarsocrural joints of healthy calves. The tarsi of 10 calves were randomly lavaged with 7.

Ultrasonographic diagnosis of porcupine quill foreign bodies in the plantar flexor tendon sheath region in a heifer.

A 17-month-old Holstein heifer was presented for persistent enlargement above the right hind fetlock of 1-month's duration. Diffuse plantar soft tissue swelling was present on the radiographs and ultrasonography revealed the presence of multiple porcupine quill extremities embedded in the subcutaneous tissue within the flexor tendon sheath wall. Surgical removal was performed.

[Chemical odor intolerance. 5 cases].

Background: Chemical odor intolerance is a benign, non-specific, generally subjective syndrome triggered by inhalation of non-toxic doses of chemical compounds or products which had been previously well tolerated. We report five characteristic cases and discuss current data.

Case Reports: Five patients (3 women, 2 men; age range 23-52 years) presented the basic criteria of chemical odor intolerance: acquired syndrome, non-specific signs (headache, nausea, vertigo .

Low molecular weight, sequence based, collagenase inhibitors selectively block the interaction between collagenase and TIMP (tissue inhibitor of metalloproteinases).

Sequence-based inhibitors of collagenase bearing an hydroxamate group capable of chelating the active site zinc atom were synthesized and tested. The effect of one of these molecules (RP 59794; Ki about 10(-8) M) on the formation of the TIMP: collagenase complex was also tested. RP 59794 blocks complex formation and can partially dissociate established TIMP: collagenase complexes.