Hand surgery and hand therapy clinical practice guideline for epidermolysis bullosa.

WHAT IS ALREADY KNOWN ABOUT THIS TOPIC?: Epidermolysis bullosa (EB) causes blistering and scarring of the hands resulting in contractures fused web spaces and altered function. Surgery is needed to release contractures and web spaces and hand therapy is essential to maintain results, approaches for both differ. WHAT DOES THIS STUDY ADD?: These guidelines aim to provide information on the surgical and conservative therapeutic hand management of children and adults diagnosed with EB.

Surgical site infection prevention bundle for children submitted to cardiac surgery.

Objective: To build and validate the content and appearance of a surgical site infection prevention bundle for children submitted to cardiac surgery.

Method: Methodological study in two phases: 1) Bundle construction from an integrative literature review from which interventions have been extracted to compose the instrument; 2) Bundle content and appearance validation by 24 judges.

Results: The 24 found articles presented 17 interventions for surgical site infection prevention in this population.

anti-trypanosomal potential of kaurane and pimarane semi-synthetic derivatives.

As part of the search for anti-trypanosomal agents, this work presents the production of sixteen derivatives. All of them were obtained from two natural diterpenes, one with kaurane skeleton (-kaurenoic acid) and other with a pimarane skeleton (-pimaradienoic acid). Then, the eighteen compounds were assayed against epimastigote form of , with the derivatives showing increase of activity in relation to their precursors.