Publications by authors named "Acıkalın M"

Purpose: Reinke's edema is a benign lesion affecting the subepithelial layer of the vocal cords, often associated with moderate or heavy smoking. Smoking is the most significant risk factor for dysplastic laryngeal lesions, laryngeal carcinomas, and Reinke's edema. Thus, Reinke's edema could potentially be a predisposing factor for laryngeal malignancy in the long term.

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  • Mucosal melanomas, particularly in the oral and sinonasal regions, present diagnostic challenges due to their varied characteristics and differentiation patterns, including neuroendocrine features.
  • A study of 18 cases revealed that 72.2% displayed neuroendocrine differentiation, suggesting it is a common feature in these types of melanoma.
  • The research highlights the importance of recognizing neuroendocrine markers (like synaptophysin, chromogranin, CD56, and INSM-1) in preventing misdiagnoses in malignant melanomas.
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  • Cutaneous melanoma frequently spreads to the parotid glands, but there's limited research on using fine-needle aspiration (FNA) to diagnose these metastatic cases.
  • This study examined four patients with parotid masses, revealing atypical cells and other features through FNA and immunohistochemical tests.
  • The findings highlight that diagnosing melanoma in such cases can be difficult without a prior history, necessitating careful consideration and additional testing to confirm the diagnosis.
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Objectives: Cribriform glands are linked to poorer outcomes in prostate adenocarcinoma. We aimed to assess the prognostic role of the percentage of cribriform glands and the size of the largest invasive cribriform gland in Gleason score 7 prostate adenocarcinomas.

Methods: The presence, percentage, and size of the invasive cribriform glands were investigated and their association with prognostic factors were assessed in 177 Grade Groups 2 and 3 prostate adenocarcinomas.

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Background: We investigated the role of European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria for the prediction of LN among children with SLE.

Methods: The data of the patients with childhood-onset SLE diagnosed based on 2012 Systemic Lupus International Collaborating Clinics (SLICC) criteria were retrospectively evaluated. Based on 2019 EULAR/ACR classification criteria, the scoring was done at the time of renal biopsy.

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  • Amyloidosis is a group of diseases caused by misfolded proteins that build up in tissues, while gout is an inflammatory arthritis caused by uric acid crystals in joints.
  • In this case, a 28-year-old man with gout was found to have AA amyloidosis affecting his medullary sponge kidney, despite gout usually not being associated with this condition.
  • The patient's family history and genetic testing did not reveal any pathogenic changes, and a renal biopsy confirmed amyloidosis; this case adds to existing literature, making it the 17th documented instance of gout linked to AA amyloidosis.
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Primary Sjogren's syndrome is a chronic autoimmune disease with glandular and extraglandular features. Renal involvement is less frequent when compared with other systemic manifestations. Glomerulonephritis is a relatively rare manifestation of primary Sjogren's syndrome.

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The eosinophilic vacuolated tumor (EVT) of the kidney is a newly identified and pathological emerging entity. In this case report, EVT diagnosed due to a partial nephrectomy performed for a suspicious kidney mass in a 47-year-old patient is presented. A review of the literature and this case indicates that EVT, also called high-grade oncocytoma, does not show clinically aggressive behavior.

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Objective: To examine and compare the immunohistochemical expressions of IL-1β, IL-6, IL-17 and TNF-α in peripheral giant cell granuloma (PGCG) and peripheral ossifying fibroma (POF).

Design: The study included 20 POF and 20 PGCG cases diagnosed at the Pathology Department of Eskişehir Osmangazi University Medical Faculty. Hematoxylin & Eosin-stained slides obtained from each biopsy specimen were re-evaluated, and IL-1β, IL-6, IL-17 and TNF-α antibodies were investigated immunohistochemically.

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Objective: The aim of the present study was to analyze the prognostic significance of tumor budding in muscle-invasive urothelial carcinomas of the urinary bladder, and also to determine an optimal threshold value in evaluation.

Patients And Methods: The study included 108 patients diagnosed with muscleinvasive conventional urothelial carcinoma between 2010 and 2020. Tumor budding was evaluated on H&E-stained slides.

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Renal oncocytoma is a benign renal tumor originated from intercalated cells of collecting ducts like chromophobe renal cell carcinoma (RCC). The differential diagnosis of these 2 tumors is important because while they are histologically and cytologically similar, they show different biological behavior. For the differential diagnosis, several immunohistochemical markers have been investigated.

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A 69-year old male patient attended our clinic with fatigue, fever, anuria, nephritic syndrome and severe renal failure. Kidney biopsy showed pauci-immune crescentic glomerulonephritis with an unusual association of suppurative interstitial nephritis. Though most patients with renal involvement linked to antineutrophil cytoplasmic antibodies associated vasculitis (AAV) have pauci-immune glomerulonephritis, only a few patients were identified to have atypical renal pathology.

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  • The rise of the internet has created "attention markets," where individuals spend more time consuming online content, but the underlying brain mechanisms driving this engagement remain unclear.
  • Researchers used functional MRI (fMRI) to study how brain activity responses to videos can predict when people choose to start or stop watching them, as well as how these patterns can indicate overall video viewing trends on platforms like YouTube.
  • The study found that brain activity at the beginning of video viewing, particularly in the nucleus accumbens and anterior insula, was linked to individual choices, while group brain activity in these areas could predict the total amount of time viewers spent watching videos, enhancing the understanding of how our brains drive online engagement.
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Regrettably the following abstract was omitted from the original publication; the abstract was submitted ahead of the submission deadline, and should have been included in the original set of abstracts.

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Introduction: In squamous cell carcinomas of the oral cavity, factors that can predict prognosis are being studied. However, new prognostic factors are needed to provide information on the biological properties of tumors. Galectin-3 is known to be involved in many biological events such as cell adhesion and differentiation, angiogenesis, apoptosis, tumorigenesis, and metastasis.

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Clear cell sarcoma of the kidney (CCSK) is an uncommon renal neoplasm of childhood. It represents between 2% and 9% of all pediatric renal tumors, and generally arises before the age of 5 years. It often mimics other pediatric renal tumors.

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Like humans, monkeys value information about sex and status, inviting the hypothesis that our susceptibility to these factors in advertising arises from shared, ancestral biological mechanisms that prioritize social information. To test this idea, we asked whether rhesus macaques (Macaca mulatta) show choice behavior that is similar to humans in response to sex and social status in advertising. Our results show that monkeys form preferences for brand logos repeatedly paired with images of macaque genitals and high status monkeys.

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Objective: We investigated the use of autologous platelet-rich plasma (PRP) to improve the success rate of fat graft myringoplasty in perforated tympanic membranes of rats.

Materials And Methods: A total of 20 healthy Wistar albino female rats were divided into two groups. In Group 1, the left tympanic membranes were perforated and grafted with a fat graft that was harvested from the inguinal region.

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Background: Nephrogenic adenoma is an uncommon benign lesion that occurs at several sites in urinary tract, from the renal pelvis to urethra, with the highest frequency in urinary bladder. Nephrogenic adenoma displays a broad spectrum of architectural and cytological features. Hence, recognition of its characteristic histopathological features is needed to distinguish this lesion from its mimickers.

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Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized with immune complex formation and renal involvement of lupus and may include several kinds of pathological conditions, but mostly, it is associated with immune complex-induced glomerular disease. Pauci-immune lupus nephritis is a very rare condition. We describe a 45-year-old female patient with pauci-immune crescentic necrotizing lupus nephritis and briefly discuss the possible mechanism and pathogenesis.

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Previous research has provided qualitative evidence for overlap in a number of brain regions across the subjective value network (SVN) and the default mode network (DMN). In order to quantitatively assess this overlap, we conducted a series of coordinate-based meta-analyses (CBMA) of results from 466 functional magnetic resonance imaging experiments on task-negative or subjective value-related activations in the human brain. In these analyses, we first identified significant overlaps and dissociations across activation foci related to SVN and DMN.

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An osseous choristoma is a rare benign lesion consisting of normal bone tissue; it is seen in abnormal locations. It is most often seen in the posterior 1/3 of the tongue in the head. Its etiopatogenesis is controversial, and till date, less than 100 cases have been reported in the literature.

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