Publications by authors named "Abulrahman Sattam Alanazi"
Fabrication and Characterization of Paclitaxel and Resveratrol Loaded Soluplus Polymeric Nanoparticles for Improved BBB Penetration for Glioma Management.
Talib Hussain Sathishbabu Paranthaman Syed Mohd Danish Rizvi Afrasim Moin Devegowda Vishakante Gowda Abulrahman Sattam Alanazi
Polymers (Basel)
September 2021
Article Synopsis
- Gliomas are challenging brain tumors with limited treatment options, and this study investigates a new combination therapy using paclitaxel (PAX) and resveratrol (RESV) delivered via polymeric nanoparticles (PNPs).
- The PAX-RESV-loaded PNPs showed effective drug encapsulation and optimal characteristics, and in lab tests, they demonstrated stronger cancer-fighting effects on glioma cells compared to using the drugs separately.
- In animal studies, the nanoparticles significantly improved the absorption and brain delivery of the drugs, suggesting that this combination therapy could be a promising strategy for treating gliomas.
Article Synopsis
- Brain tumors account for about 3% of cancer-related deaths, with a focus on their prevalence and treatment options in Saudi Arabia, including the role of nanotechnology.
- A literature review highlighted that gliomas, astrocytomas, meningiomas, and metastatic cancers have higher incidence rates in Saudi Arabia and are primarily treated with conventional methods, which often lead to a poor prognosis.
- Nanomaterials, particularly polymer-based formulations, show promise in enhancing brain cancer treatment outcomes and reducing toxicity to normal cells, but further clinical studies are needed to establish their safety and efficacy.