In Vitro, In Silico and Network Pharmacology Mechanistic Approach to Investigate the -Glucosidase Inhibitors Identified by Q-ToF-LCMS from Fruit Subcritical CO Extract.

The fruit of have been traditionally used as an antidiabetic remedy in Malaysia and neighbouring countries. Despite its potential for diabetes treatment, no scientific study has ever been conducted to predict the inhibitor interaction of the protein -glucosidase identified in an extract prepared with a non-conventional extraction technique. Hence, the major aim of this research was to evaluate the in vitro antioxidant, the -glucosidase inhibitors, and the molecular dynamic simulations of the -glucosidase inhibitors identified by Quadrupole Time-of-Flight Liquid Chromatography Mass Spectrometry (Q-ToF-LCMS) analysis.