Publications by authors named "Abuhandan M"

Article Synopsis
  • The study investigates the prevalence of adrenocortical hypofunction (ACH) in patients with β-thalassemia, focusing on their cortisol, aldosterone, and DHEAS levels compared to healthy individuals.
  • Approximately 38% of thalassemia patients displayed some form of adrenal zone hypofunction, with significant correlations found between ACH severity and factors like age and total body iron load (TBIL).
  • Cardiac MRI was identified as a useful tool to predict the severity of ACH in these patients.
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Background/aim: Vitamin B12 plays an important role in the development of mental, motor, cognitive, and social functions via its role in DNA synthesis and nerve myelination. Its deficiency in infants might cause neuromotor retardation as well as megaloblastic anemia. The objective of this study was to investigate the effects of infantile vitamin B12 deficiency on evoked brain potentials and determine whether improvement could be obtained with vitamin B12 replacement at appropriate dosages.

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Background: Burning fat and carbohydrates to provide energy in biological systems causes the formation of free oxygen species.

Objectives: This study aimed to evaluate the oxidative status of serum and breast milk of mothers giving birth prematurely and at full-term.

Materials And Methods: The study comprised 50 mothers who gave birth at full-term at more than 38 weeks and 43 mothers who gave birth pre-term at below 32 weeks.

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Objective: The study aimed to evaluate the pre-treatment and post-treatment oxidant capacity, antioxidant capacity and S100B protein levels in cases of diabetic ketoacidosis (DKA).

Methods: The study included 49 pediatric patients diagnosed with DKA and a control group comprising 49 healthy children. Blood samples were obtained after confirmation of the DKA diagnosis and also after treatment.

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Objective: Breath-holding spells are common paroxysmal events in children. Although the spells have a benign prognosis in the long term, they may be complicated by loss of consciousness, tonic-clonic movements, and occasionally seizures. Hence, this study aimed to measure the levels of serum S-100B proteins and neuropeptide-Y in the blood of children who experience breath-holding spells.

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Objective: This study aimed to evaluate serum selenium levels and mean platelet volume in children who experience simple febrile convulsion.

Methods: The study comprised 42 patients diagnosed with simple febrile convulsions and a control group of 30 healthy children. Blood samples were taken following a febrile convulsion.

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Objective: This study aimed to measure paraoxonase/arylesterase activities and to evaluate the total oxidant and antioxidant capacities in obese children and in children with metabolic syndrome (MetS).

Methods: A total of 151 children of comparable ages (13.23±1.

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Objectives: Upper air obstruction leads hypoxia, it is also known that S-100B levels increase by glial activations indicate cerebral hypoxic injury. This study aimed to evaluate the preoperative and postoperative S-100B levels in children with chronic adenotonsillar hypertrophy.

Patients And Methods: The study comprised 40 patients with indications for tonsillectomy and/or adenoidectomy following a diagnosis of chronic adenotonsillar hypertrophy and 40 age-gender matched control patients.

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Background: Iron chelation therapy is an important component in the management of patients with β-thalassemia.

Methods: The study included 87 children with transfusion-dependent β-thalassemia aged 2-17 years (mean, 8.2 ± 4.

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Epilepsy is the most common neurologic disorder of childhood. In approximately 6-14% of all patients with epilepsy, complete seizure control is difficult to achieve with current antiepileptic treatments. Several current studies have shown in both animals and people that the lengthening of epileptic seizures and frequent recurrence increases the likelihood of neuronal damage.

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Various psychological, social, genetic and biochemical factors are thought to be involved in etiology of obsessive-compulsive disorder (OCD). To the best of our knowledge there are no studies investigating the effects of free radicals in children and adolescents with OCD. This study evaluated total oxidant and antioxidant status, oxidative stress index, and arylesterase and paraoxonase activity in children and adolescents with OCD.

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Article Synopsis
  • Fructose-1,6-bisphosphatase (FBPase) deficiency is a genetic disorder leading to severe hypoglycemia and impaired gluconeogenesis, which can be fatal if untreated.
  • Two Turkish siblings were diagnosed with FBPase deficiency, having a specific mutation in the FBP1 gene that contributed to their condition.
  • The first case involved a 2-year-old girl who improved significantly after treatment, while her 5.5-year-old brother also experienced hypoglycemic attacks, revealing the genetic link and parents' consanguinity.
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Aim: This study aimed to evaluate the preoperative and postoperative oxidative status of children with chronic adenotonsillar hypertrophy.

Materials And Methods: The study comprised 25 patients with indications for tonsillectomy and/or adenoidectomy following a diagnosis of chronic adenotonsillar hypertrophy and 25 age-gender matched control patients were included to the study. Blood samples were taken from the patients preoperatively and at four weeks postoperatively.

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Aim: This study aimed to evaluate the neuropeptide Y values of patients with subacute sclerosing panencephalitis.

Materials And Methods: The study comprised 38 patients diagnosed with subacute sclerosing panencephalitis at our clinic, who were being routinely followed-up, together with a control group of 36. Using the Risk and Haddad classification for clinical staging, 16 patients were determined as Stage II and 22 patients as Stage III.

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Article Synopsis
  • - The study focuses on the severe clinical effects of vitamin B12 deficiency in children from developing countries and emphasizes the urgent need for early diagnosis and treatment to prevent serious health complications.
  • - Researchers evaluated 41 hospitalized children diagnosed with severe vitamin B12 deficiency, confirming low serum vitamin B12 levels and assessing their developmental status through a standardized inventory.
  • - Results showed that patients exhibited various symptoms, such as growth retardation and skin hyperpigmentation, but all recovered with vitamin B12 treatment, highlighting the critical importance of timely medical intervention.
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Article Synopsis
  • The study aimed to assess the oxidative status in children experiencing simple febrile seizures after a seizure incident.
  • Researchers compared 32 children who had experienced a seizure due to a respiratory infection with 30 healthy controls, measuring oxidant and antioxidant levels in their blood.
  • Results indicated that children with febrile seizures had significantly higher total oxidant levels and lower antioxidant levels, suggesting increased oxidative stress may elevate the risk of future seizures.
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Objective: This study aimed to evaluate antibiotic resistance in the province of Şanliurfa and to observe any difference between antibiotic resistance rates.

Material And Methods: The study comprised 107 children who presented at the pediatric polyclinic with complaints of urinary tract infection with the diagnosis of urinary tract infection and whose urine cultures exhibited bacterial growth. The patients were analyzed with respect to the frequency of proliferating pathogens, sensitivity to the antibiotics used and the rates of developed resistance to the antibiotics.

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Subacute sclerosing panencephalitis (SSPE) is a progressive inflammatory and degenerative disorder of the central nervous system. The measles virus (MV) and host and environmental factors are involved in the development of SSPE, but the precise mechanism by which the MV causes SSPE is still unknown. Studies have indicated that in SSPE patients, specific polymorphisms of certain genes are most likely involved in impairing the host's ability to eradicate the MV.

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Objective: Heart rate variability (HRV) measures are altered in various cardiac and non-cardiac situations in children. The autonomic nervous system is assumed to have a role in the pathophysiology of atrial septal defect (ASD). In this study, we evaluated the autonomic system by measuring HRV in children with ASD.

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Subacute sclerosing panencephalitis (SSPE) is a progressive inflammatory and degenerative disorder of the central nervous system. Several factors influence the risk of chronic brain infection with the mutant measles virus. However, to date, no pathogenic mechanism that may predispose to SSPE has been determined.

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Background: Breath-holding spells (BHS) are the most common form of non-epileptic paroxysmal events in infancy. The pathophysiology of BHS is not fully understood. Iron-deficiency anemia (IDA) may be a factor contributing to breath-holding spells.

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Purpose: The aim of the study is to evaluate neonatal bilirubin encephalopathy in the acute period by the DWI.

Materials And Methods: Thirty newborn babies with hyperbilirubinemia at the gestational age of 38-40 weeks, diagnosed with acute neonatal bilirubin encephalopathy as a result of clinical findings were included in the study, and a further 24 newborn babies, whose ages, weights and gestational ages were equalized, were regarded as a control group. DWI was performed on both patient and control groups.

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Purpose: An elevated level of S-100B in serum is generally considered to be a biochemical marker of nervous tissue damage. According to our knowledge, no studies have evaluated the serum S-100B protein concentration in children with temporal lobe epilepsy. The objective of this study was to measure the serum levels of S-100B protein in pediatric cases with temporal epilepsy.

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Purpose: This study aimed to evaluate the contribution of diffusion weighted magnetic resonance imaging to the diagnosis and staging of subacute sclerosing panencephalitis.

Material And Method: The study comprised 26 patients diagnosed with subacute sclerosing panencephalitis at our clinic who were undergoing regular follow-up, and a control group of 18 subjects. Clinical staging was determined by Risk and Haddad classification; 12 at Stage II and 14 at Stage III.

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Aim: The study aimed to research the effect of maternal age at pregnancy on the paraoxonase (PON) and arylesterase activity levels of mothers and infants.

Method: The study comprised 30 mothers aged more than 35 years and their infants, and 30 mothers aged under 25 years and their infants. All pregnancies had been of 38-42 weeks with normal spontaneous vaginal birth.

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