Geoelectrical resistivity and geochemistry monitoring of landfill leachates due to the seasonal variations and the implications on groundwater systems and public health.

Understanding the seasonal variations in the landfill leachate plumes (LLPs) properties and complex connections between concentrations of leachate variability, and its environment is essential for environmental and public health management. This study explores the combined electrical resistivity (ER) data and physiochemical water analysis (PWA) coupled with the excavations to monitor the landfill physiochemical properties (LPPs) due to seasonal variations and their implications on environmental vital organs and public health. The variations in ER and LLP distributions across the overburdened top layer due to seasonal changes were examined.

Evaluation of gold mineralisation potential using AHP systems and weighted overlay analysis.

The demand for sustainable development goals and the absence of systematic development and organised exploration for gold has prompted this study to integrate magnetic and radiometric datasets with lithology to evaluate the gold mineralisation potential in the Ilesha schist belt. This study considers 3168.72 km of the Ilesha schist belt in southwestern Nigeria, a frontier belt for gold deposits.

Exploring factors influencing sustainable human capital development: Insights from Saudi Arabia.

This study investigates the critical factors influencing Saudi Arabia's sustainable human capital development. It primarily aims to explore the correlations among the postulated variables and how each variable influences the development of a skilled, adaptable, and socially conscious workforce, in alignment with the objectives of the Saudi Vision 2030. This study utilizes a quantitative approach, employing partial least squares structural equation modeling to analyze the data collected from 203 public personnel in Saudi Arabia through an online questionnaire.

Phase-Resolved Partial Discharge (PRPD) Pattern Recognition Using Image Processing Template Matching.

This paper proposes a new method for recognizing, extracting, and processing Phase-Resolved Partial Discharge (PRPD) patterns from two-dimensional plots to identify specific defect types affecting electrical equipment without human intervention while retaining the principals that make PRPD analysis an effective diagnostic technique. The proposed method does not rely on training complex deep learning algorithms which demand substantial computational resources and extensive datasets that can pose significant hurdles for the application of on-line partial discharge monitoring. Instead, the developed Cosine Cluster Net (CCNet) model, which is an image processing pipeline, can extract and process patterns from any two-dimensional PRPD plot before employing the cosine similarity function to measure the likeness of the patterns to predefined templates of known defect types.

Identification of HPV16's E6 gene in suspected cases of cervical lesions and docking Study of its L1 protein with active components of .

Background: HPV 16 is the primary etiologic agent of cervical cancer and the presence of L1 and E6 oncoproteins are largely responsible for its virulence. It was the objective of this study to identify HPV16 isolates from suspected cases of cervical cancer at Specialist Hospital Sokoto and Sir Yahaya Memorail Hospiatal Birnin Kebbi, Nigeria and also to identify potent HPV16's L1 protein inhibitor using in silico analysis.

Methods: A total of 144 cervical samples consisting of 21 low grade squamous intraepithelial lesion, 6 high grade lesion and 117 negative pap smears were collected.

Potential of diterpenes as antidiabetic agents: Evidence from clinical and pre-clinical studies.

Diterpenes are a diverse group of structurally complex natural products with a wide spectrum of biological activities, including antidiabetic potential. In the last 25 years, numerous diterpenes have been investigated for antidiabetic activity, with some of them reaching the stage of clinical trials. However, these studies have not been comprehensively reviewed in any previous publication.

Phloroglucinol as a Potential Candidate against Infection: Insights from In Vivo, In Vitro, Molecular Docking and Molecular Dynamic Simulation Analyses.

Sub-Saharan Africa is profoundly challenged with African Animal Trypanosomiasis and the available trypanocides are faced with drawbacks, necessitating the search for novel agents. Herein, the chemotherapeutic potential of phloroglucinol on infection and its inhibitory effects on the partially purified sialidase and phospholipase A (PLA) were investigated. Treatment with phloroglucinol for 14 days significantly ( < 0.

Sesquiterpene lactones from and their quorum sensing inhibitory activity.

The leaves of , with the synonym are widely used as purgative agents for gastrointestinal problems, and other members of Vernonieae have been used in African traditional medicine for decades. A new sesquiterpene lactone of the keto-hirsutinolide type, 13-acetoxy-1(4),5(6)-diepoxy-8-(senecioyloxy)-3-oxo-1,7(11)-germacradiene-12,6-olide , was isolated from the hexane extract of its leaves, in addition to the known 13-acetoxy-1,4-epoxy-8-(senecioyloxy)-3-oxo-1,5,7(11)-germacratriene-12,6-olide . Three common flavonoids (apigenin , luteolin and velutin ) were also isolated.

Antidiabetic potential of anthraquinones: A review.

The present study was designed to review the antidiabetic potential of anthraquinones (AQs) with emphasis on the extent of blood glucose reduction, the half maximal inhibitory concentration values (in vitro studies), the proposed mechanisms of action, and the structure activity relationship studies. We sourced relevant data from the major scientific databases (Pubmed, Science Direct, Medline, and Google Scholar). According to our search, 25 AQs have shown variable antidiabetic potential, whereas one AQ (morindone-6-O-β-D-primeveroside) showed no blood glucose-lowering ability.

Geological influence on the activity concentration of terrestrial radionuclides Ra, Th and K in the Jos Plateau, Nigeria.

The Jos Plateau has been reported to have elevated levels of natural background radiation. A few earlier studies have measured the levels of natural radioactivity for specific locations in the area. Our interest is to investigate how geology of the study area influences the activity concentrations of natural radionuclides.

A systematic review of pentacyclic triterpenes and their derivatives as chemotherapeutic agents against tropical parasitic diseases.

Parasitic infections are among the leading global public health problems with very high economic and mortality burdens. Unfortunately, the available treatment drugs are beset with side effects and continuous parasite drug resistance is being reported. However, new findings reveal more promising compounds especially of plant origin.

Quorum sensing inhibitory potential and molecular docking studies of sesquiterpene lactones from Vernonia blumeoides.

The increasing incidence of multidrug-resistant Gram-negative bacterial pathogens has focused research on the suppression of bacterial virulence via quorum sensing inhibition strategies, rather than the conventional antimicrobial approach. The anti-virulence potential of eudesmanolide sesquiterpene lactones previously isolated from Vernonia blumeoides was assessed by inhibition of quorum sensing and in silico molecular docking. Inhibition of quorum sensing-controlled violacein production in Chromobacterium violaceum was quantified using violacein inhibition assays.

An overview of current knowledge concerning the health and environmental consequences of the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident.

Since 2011, the scientific community has worked to identify the exact transport and deposition patterns of radionuclides released from the accident at the Fukushima Daiichi Nuclear Power Plant (FDNPP) in Japan. Nevertheless, there still remain many unknowns concerning the health and environmental impacts of these radionuclides. The present paper reviews the current understanding of the FDNPP accident with respect to interactions of the released radionuclides with the environment and impacts on human and non-human biota.

Chemical composition and antimicrobial activity of hexane leaf extract of Anisopus mannii (Asclepiadaceae).

Objective: The aim was to determine the chemical constituents and antimicrobial activity of the hexane leaf extract of Anisopus mannii against a wide range of human pathogenic microorganisms.

Methods: The chemical constituents of the hexane leaf extract was determined using gas chromatography-mass spectrometry (GC-MS) analysis; and the antimicrobial activity was evaluated on "standard strains", clinical susceptible and resistant bacterial and fungal isolates using the disc diffusion and broth microdilution methods.

Results: GC-MS analysis of the hexane leaf extract revealed 32 compounds, representing 73.

Radioecological impacts of tin mining.

The tin mining activities in the suburbs of Jos, Plateau State, Nigeria, have resulted in technical enhancement of the natural background radiation as well as higher activity concentrations of primordial radionuclides in the topsoil of mining sites and their environs. Several studies have considered the radiological human health risks of the mining activity; however, to our knowledge no documented study has investigated the radiological impacts on biota. Hence, an attempt is made to assess potential hazards using published data from the literature and the ERICA Tool.

Health and ecological hazards due to natural radioactivity in soil from mining areas of Nasarawa State, Nigeria.

Nasarawa State is located in north central Nigeria and it is known as Nigeria's home of solid minerals. It is endowed with barite, copper, zinc, tantalite and granite. Continuous releases of mining waste and tailings into the biosphere may result in a build-up of radionuclides in air, water and soil.

Blood pressure and heart rate adjustment following acute Frenkel's ambulatory exercise in chronic hemiparetics stroke survivors: a comparative study.

Background: Frenkel's ambulatory activity has been routinely employed by physiotherapists for rehabilitation of gait coordination, however, its immediate influence on blood pressure and heart rate has not been investigated.

Objective: To investigate the acute effect of Frenkel's ambulatory activity on blood pressure and heart rate of chronic hemiparetic stroke survivors.

Method: Using a comparative study design, 60 chronic hemiparetic stroke survivors of varying onset of stroke, ≤6, >6-11 and ≥12 months were subjected to a 2-minute Frenkel's ambulatory activity on marked footsteps (from standard adult described footsteps).

Sesquiterpene lactones from the aerial parts of Vernonia blumeoides growing in Nigeria.

Four eudesmanolide sesquiterpene lactones (1-4) were isolated from the aerial parts of Vernonia blumeoides used in Nigerian ethnomedicine for the treatment of diarrhea and malaria. Compound 1 demonstrated limited but interesting antibacterial activity against Bacillus, Staphylococcus and Streptococcus species. The crystal structure of 1 allowed the absolute configuration of the stereocentres in the molecule to be assigned.

A New Antimicrobial Prenylated Benzo-lactone from the Rhizome of Cissus cornifolia.

Background: Medicinal plants remain one of the largest reservoirs of new bioactive compounds. In this study, a new prenylated benzo-lactone (4, 6-dihydroxy-5-methoxy-3-(1, 2, 3, 4, 5-pentahydroxypentyl)-2-benzofuran-1(3H)-one) was isolated from the acetone extracts of the rhizome of Cissus cornifolia. The antimicrobial activity of the compound was evaluated against some microorganisms including Staphylococcus aureus, Salmonella typhi, and Candida albicans.

Fukushima nuclear accident: preliminary assessment of the risks to non-human biota.

This study assesses the 'radio-ecological' impacts of Fukushima nuclear accident on non-human biota using the ERICA Tool, which adopts an internationally verified methodology. The paper estimates the impacts of the accident on terrestrial and marine biota based on the environmental data reported in literature for Japan, China, South Korea and the USA. Discernible impacts have been detected in the marine biota around Fukushima Daiichi nuclear power plant.

Anti-trypanosomal activity of African medicinal plants: a review update.

Ethnopharmacological Relevance: African trypanosomiasis is one of the neglected tropical diseases caused by different species of trypanosomes that affect both human and livestock with devastating consequences in the continent. Most of the affected populations commonly use traditional medicinal plants for the treatment of the disease. Consequently, this prompted ethnopharmacological research activities on the anti-trypanosomal activity of a number of these African medicinal plants in order to validate their ethnomedicinal use.

Saponins-rich fraction of Calotropis procera leaves elicit no antitrypanosomal activity in a rat model.

Objective: To examine the in vitro and in vivo anti-Trypanosoma evansi (T. evansi ) activity of saponins-rich fraction of Calotropis procera (cpsf) leaves as well as the effect of the fraction on the parasite-induced anemia.

Methods: A 60-minutes time course experiment was conducted with various concentrations of the fraction using a 96-well microtiter plate technique, and subsequently used to treat experimentally T.

Assessment of environmental (226)Ra, (232)Th and (40)K concentrations in the region of elevated radiation background in Segamat District, Johor, Malaysia.

Extensive environmental survey and measurements of gamma radioactivity in the soil samples collected from Segamat District were conducted. Two gamma detectors were used for the measurements of background radiation in the area and the results were used in the computation of the mean external radiation dose rate and mean weighted dose rate, which are 276 nGy h(-1) and 1.169 mSv y(-1), respectively.

Phenolics-rich fraction of Khaya senegalensis stem bark: antitrypanosomal activity and amelioration of some parasite-induced pathological changes.

Context: The stem bark of Khaya senegalensis A. Juss (Meliaceae) is currently used for the treatment of trypanosomiasis by traditional practitioners in Nigeria.

Objectives: The present study investigated the anti-Trypanosoma brucei brucei activity of phenolics-rich fraction of K.

Free radical scavenging and total antioxidant capacity of root extracts of Anchomanes difformis Engl. (Araceae).

Antioxidants activities from plants sources have attracted a wide range of interest across the world in recent times. This is due to growing concern for safe and alternative sources of antioxidants. The free radical scavenging activity using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), reducing power assay, total antioxidant capacity of the phosphomolybdenum method and the total phenolics content using the Folin-Ciocalteu reagent were carried out on the acetone, n-butanol and methanol root extracts of Anchomanes difformis.