Publications by authors named "Abu-Hilal M"
Background: Hepato-Pancreato-Biliary (HPB) surgery is a complex specialty and Artificial Intelligence (AI) applications have the potential to improve pre- intra- and postoperative outcomes of HPB surgery. While ethics guidelines have been developed for the use of AI in clinical surgery, the ethical implications and reliability of AI in HPB surgery remain specifically unexplored.
Methods: An online survey was developed by the Innovation Committee of the E-AHPBA to investigate the current perspectives on the ethical principles and trustworthiness of AI in HPB Surgery among E-AHPBA membership.
Purpose: To assess the association between neoadjuvant therapy and overall survival (OS) in patients with left-sided resectable pancreatic cancer (RPC) compared to upfront surgery.
Background: Left-sided pancreatic cancer is associated with worse OS compared to right-sided pancreatic cancer. Although neoadjuvant therapy is currently seen as not effective in patients with RPC, current randomized trials included mostly patients with right-sided RPC.
Background: Ampullary adenocarcinoma (AAC) typically presents at an early stage due to biliary obstruction and therefore might be specifically suitable for minimally invasive pancreatoduodenectomy (MIPD). However, studies assessing MIPD specifically for AAC, including the robotic and laparoscopic approach, are limited. The aim of this study is to compare short- and long-term oncological resection and perioperative outcomes of robotic (RPD), laparoscopic (LPD) and open pancreatoduodenectomy (OPD) performed specifically for AAC.
View Article and Find Full Text PDFMycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma (CTCL), representing the majority of all lymphomas arising in the skin. The disease treatment focuses on managing symptoms and preventing disease evolution. To date, there is no gold standard for MF-CTCL treatment.
View Article and Find Full Text PDFBackground: The use of minimally invasive (laparoscopic and robotic) pancreatoduodenectomy (PD) is being increasingly adopted despite the lack of hard evidence to support its utilisation. With recent randomised controlled trials (RCTs) comparing open pancreatoduodenectomy (OPD) with robotic or laparoscopic pancreatoduodenectomy (RPD or LPD), we undertook a network meta-analysis (NMA) comparing all 3 approaches to evaluate comparative outcomes.
Methods: A systematic search of MEDLINE, EMBASE, and Cochrane CENTRAL was conducted up to May 2024 and relevant RCTs were identified.
Objective: To compare nationwide outcomes of robotic liver resection (RLR) with laparoscopic liver resection (LLR).
Background: Minimally invasive liver resection is increasingly performed using the robotic approach as this could help overcome inherent technical limitations of laparoscopy. It is unknown if this translates to improved patient outcomes.
Objective: To validate the ISGPS complexity grading system for minimally invasive pancreaticoduodenectomy (MIPD).
Background: Although concerns about patient safety persist, MIPD is gaining popularity. The ISGPS recently introduced a difficulty grading system to improve patient selection by aligning procedural complexity with surgeon and center expertise.
Background: Tildrakizumab is an interleukin-23 inhibitor approved in Canada in 2021 for the treatment of adults with moderate-to-severe plaque psoriasis.
Objectives: To evaluate real-world effectiveness of tildrakizumab for the treatment of moderate-to-severe plaque psoriasis in Canada.
Methods: A multicenter, retrospective study was conducted in Canada in adults with moderate-to-severe plaque psoriasis for ≥1 year treated with tildrakizumab for ≥12 weeks.
Article Synopsis
- Atopic dermatitis (AD) is a chronic skin condition that can severely affect patients' quality of life, including their sexual well-being.
- A study assessed the impact of moderate-to-severe AD on sexual health and the effectiveness of two treatments, abrocitinib and dupilumab, over a year.
- Results showed that before treatment, a large majority of patients felt their condition affected their sex life negatively, but after 52 weeks of therapy, these negative feelings and behaviors significantly decreased.
Importance: Postoperative pancreatic fistulas (POPF) are the biggest contributor to surgical morbidity and mortality after pancreatoduodenectomy. The impact of POPF could be influenced by the surgical approach.
Objective: To assess the clinical impact of POPF in patients undergoing minimally invasive pancreatoduodenectomy (MIPD) and open pancreatoduodenectomy (OPD).
Dermatomyositis (DM) is an idiopathic inflammatory myopathy characterized by progressive muscle weakness and distinctive cutaneous findings. The exact incidence and prevalence of DM in the general population is largely unknown, and data on demographic and clinical features in patients in Canada are lacking. This study aimed to comprehensively evaluate the patients with DM in Southwestern Ontario, Canada.
View Article and Find Full Text PDFBackground: Previous meta-analyses have yielded conflicting results on the optimal surgical treatment strategy in patients with synchronous colorectal liver metastases (sCRLM). This network meta-analysis aims to provide an overview on colorectal-, liver first and simultaneous resections to treat sCRLM.
Methods: A search was conducted in MEDLINE, Embase and Cochrane CENTRAL (inception-July 11,2023).
We present two pediatric cases of nontraumatic myositis ossificans (MO), which initially mimicked infections, leading to unnecessary treatments. The first case involves an 11-year-old boy with acute left hip pain and swelling, misdiagnosed as a hip joint infection and treated with antibiotics before histology confirmed MO. The second case is a two-year-old girl who presented with limping and restricted hip movement, initially suspected to have septic arthritis.
View Article and Find Full Text PDFObjective: To validate the ISGPS definition and grading system of PPAP after pancreatoduodenectomy (PD).
Summary Background Data: In 2022, the International Study Group for Pancreatic Surgery (ISGPS) defined post-pancreatectomy acute pancreatitis (PPAP) and recommended a prospective validation of its diagnostic criteria and grading system.
Methods: This was a prospective, international, multicenter study including patients undergoing PD at 17 referral pancreatic centers across Europe, Asia, Oceania, and the United States.
Article Synopsis
- Atopic dermatitis can greatly affect pregnant women’s health and quality of life, necessitating effective treatments that ensure safety for both mothers and their babies.
- The systematic review analyzed 13 studies involving 68 patients, leading to findings of 58 live births and 11 spontaneous abortions, indicating that dupilumab therapy can improve dermatitis and has low risks during pregnancy.
- Most pregnancies went smoothly, with 82.4% of deliveries being vaginal and 92.3% of newborns having a normal birth weight, but further research is needed for long-term safety confirmation of dupilumab use in pregnant patients.
Article Synopsis
- * Out of 3,530 patients, 11.6% required conversion, with robotic procedures having a lower conversion rate compared to laparoscopic ones, and conversion associated with various complications, like increased blood loss and longer hospital stays.
- * Emergency conversions showed even more severe outcomes, such as significantly higher blood loss and increased rates of intensive care admissions compared to non-emergency cases.
Article Synopsis
- A new surgery technique called minimally invasive pancreatoduodenectomy (MIPD) is being studied as a possible better option than the traditional open surgery (OPD) for pancreas problems.
- Researchers looked at data from hospitals in North America, Germany, the Netherlands, and Sweden from 2014 to 2020 and found that MIPD is used differently in each country.
- They discovered that more patients were getting MIPD over time, especially in North America and the Netherlands, but there were also higher risks of complications in some cases.