Efficacy and Safety of Divaza for the Correction of Oxidative Disturbances in Patients with Cerebral Atherosclerosis: A Randomized Controlled Trial.

Objective: The objective of this study was to determine if Divaza, a drug with nootropic and antioxidant effects, was safe and effective for the correction of oxidative disturbances and to stabilize cognitive impairment in patients with cerebral atherosclerosis.

Study Design: The study design consisted of a 12-week multicenter, randomized, double-blind, placebo-controlled, prospective trial in parallel groups.

Setting: The setting in which the study was conducted comprised 10 clinical centers across the Russian Federation.

Management of Cough in Patients with Chronic Obstructive Pulmonary Disease: Results of the Multicenter Randomized Placebo-Controlled Clinical Trial.

Background: Chronic cough declines quality of life and increases risk of complications in patients with chronic obstructive pulmonary disease (COPD). Reducing cough severity and associated negative effects is important therapeutic goal in COPD. Rengalin with anti- and protussive activity is based on technologically processed antibodies to bradykinin, histamine and morphine.

[Evaluation of respiratory parameters in patients with chronic obstructive lung disease during physical exercises].

Aim: To study the relationship between the indicators of dynamic capnography and pulse oximetry with the indicators of the 6-minute walk test (6MWT) in patients with chronic obstructive pulmonary disease (COPD).

Materials And Methods: 67 patients of both sexes were examined: 45 patients with COPD (age 60.02.

[The medical social importance of functional disorders under chronic obstructive disease of lungs].

The chronic obstructive disease of lungs is considered as important problem of modern public health system. The disease is increasingly keenly reflected in agenda of our society, economic and social sphere of the state. The steadily progressing course of disease, disability and increasing economic costs assigns task of finding and improving diagnostic methods in real clinical practice.

On respiratory manifestations of gastroesophageal reflux disease.

One of the manifestations of gastroesophageal reflux disease (GERD) is extraesophageal symptoms, in particular, from the upper and lower respiratory tract. Gastroesophageal reflux is capable of both causing respiratory symptoms independently and aggravating the course of already existing diseases of the respiratory system. The article presents available in the literature current information on the pathogenesis of GERD respiratory symptoms, their clinical course, considerations of diagnosis and treatment.

[The artificial joint in the biological environment].

The mechanisms of the joint endoprothesis components evolution and wear as well as development periarthric tissue membrane are discussed. The loosing process is connected with immuno-inflammatory reactions in periarthric tissues on products' wear and modified proteins which activate the bone resorption and/or proliferative reactions as ectopic bone formation. Systemic effects of artificial joints can be connected with migration of metal ions and primated in periarthric tissues of immunocompetent cells.

[Alternation of protease inhibitors and hemostasis system in treatment of spontaneous pneumothorax].

3 groups of 37 patients were examined, in which for treatment of spontaneous pneumothorax drainage of pleural cavity and medicamentous pleurodesis with tetracycline hydrochloride and 4% solution of sodium bicarbonate were used. Interdependence of clinical criteria and level of protease inhibitors were evaluated, as well as the basic components of hemostasis. The best effectiveness of treatment in carrying out chemical pleurodesis was demonstrated, especially when 4% sodium bicarbonate solution was used.

[Endoscopic treatment methods in patients with the postcholecystectomy syndrome].

458 patients with postcholecystectomy syndrome have been examined. In 289 (63.1%) of them the reason of complication and location of the lesion in biliopancreatic-duodenal zone have been specified.

[Instrumental methods in the treatment of non-specific spontaneous pneumothorax].

The results of treatment of 226 patients with unspecific spontaneous pneumothorax in 1980-1990 are discussed. Poor efficacy of punctures of the pleural cavity (32.4%) is noted.

[Possibilities of using the biofeedback method in the combined modality therapy of patients with bronchial asthma].

The efficacy of biological feedback was studied in multimodality treatment of patients suffering from bronchial asthma. Use was made of a device modified by the authors themselves. In that device, the system of the patient's respiration control was synchronized with the block of diaphragmatic pacing.

[The hyperventilation syndrome: the treatment problems].

The principal methods of the treatment of the hyperventilation syndrome (HVS) are reviewed. The following methods of the action on the patient are distinguished: psychotherapy, pharmacotherapy, remedial gymnastics, correction of respiratory disorders according to the principle of the biological feed-back mechanism, recurrent respiration or carbon dioxide inhalations. Emphasis is laid on the importance of an individual approach to the institution of the treatment measures.

[Bronchial asthma, elevated bronchial reactivity and physical loading].

The paper is concerned with a comparative study of the evidence of case histories, clinical symptomatology, external respiratory function and the effect of beta-adrenergic drugs in patients with bronchial asthma to define conditions contributing to the development of a bronchospasm caused by submaximum physical exertion. It was shown that submaximum physical exertion was followed by marked bronchial obstruction in 60% of patients. A degree of bronchospasm caused by physical exertion was in direct relation to a patient's age, the duration of disease and a period from the onset of disease.

[The hyperventilation syndrome].

A review of literature comprises the main data on etiological factors, pathogenetic mechanisms, clinical peculiarities and methods of diagnosis of the hyperventilation syndrome. Physicians' insufficient knowledge of this disease is emphasized. Various clinical manifestations are based on the same pathogenetic mechanisms of acute or chronic respiratory disregulation resulting in hypocapnia, a rise of vascular tone, and electrolytic disorders.