[Parathyrin content of lung cancer patients undergoing surgical and chemotherapeutic treatment].

Parathyrin concentration was determined in lung cancer patients prior to and after operation by using a radiological method. A preoperative elevated level of parathyrin was noted in 60.4% of the patients.

[Modern possibilities of the surgical treatment of lung cancer].

The twenty-year experience gained in the surgical treatment of 1,100 cases of lung cancer at the Clinic of Thoracic Oncology and Reanimation Department of the Center is summarized. Surgical and anesthetic procedures, premedication and methods of postoperative intensive care following resection or removal of the lung are discussed. The paper contains a detailed description of age-associated and concommitant diseases.

[Combined (surgical and drug) therapy of lung cancer].

The paper deals with an evaluation of the immediate and end results as well as the rates of lung tumor progression in the course of surgical and combined therapy including different schedules of long-term administration of preparation CCNU. Combined therapy was shown to be followed by a longer remission and survival, as compared with cancer patients in control. The said effect was particularly pronounced is cases of squamous-cell carcinoma and in patients treated with levomycetin.

[Carcinoembryonic antigen in lung cancer patients].

Radioimmunoassay of carcino-embryonic antigen was conducted in lung cancer patients before and after surgery. Elevated concentrations of the antigen before operation was registered in 84.8% of cases.

Conformational changes induced by hapten in pig antibodies to the dinitrophenyl group. Analysis by temperature-perturbation and solvent-perturbation spectroscopy.

Pig antibodies to the dinitrophenyl group and fragments derived from them by limited proteolysis were studied by temperature-perturbation and solvent-perturbation spectroscopy with particular attention to differences between the number of perturbed chromophores in free antibodies and in antibody-hapten complexes. The position of the maxima in the difference spectra show that solvent-perturbed chromophores are exposed to water, but thermally perturbed chromophores are located in a microenvironment the polarity of which corresponds to 25-50% ethylene glycol. A significant fraction of tyrosine residues (65-90%) and tryptophan residues (20-45%) is perturbed by temperature.

[Possibilities for the early detection of lung cancer recurrences and metastases].

The results of surgical treatment in 260 lung cancer patients are analysed. The purposeful dynamic examination of patients by modern technics enabled a recognition of progressive tumor growth in 112 of 137 patients (81,75%) during the first 18 months after the operation. To reveal subclinical recurrences and metastases in the chest organs roentgenological and bronchological methods, positive 67Ga-citrate scintigraphy seem to be preferable.