Development of polymeric films embedded with liquid nanodomains.

Modified microemulsions (MEs), termed by us nanodomains (NDs), seem to be suitable vehicles for dermal drug delivery due to their high surface area and the interface enriched with membrane recognizing agents, penetration enhancers, and other components. However, liquid nanodomains do not provide a controlled release of the bioactive through the skin. Therefore, the main goal of our present study is to develop a film polymeric platform embedded with liquid nanovehicles for the controlled release of drugs.

Incorporation of curcumin in liquid nanodomains embedded into polymeric films for dermal application.

Liquid nanovehicles are gaining interest in drug delivery because of the high solubilization capacity of bioactives at their interface and enhanced permeation of compounds across physiological membranes. However, the dermal application of liquid nanovehicles is still limited. The goal of this research is to develop a dermal delivery system based on embedding of liquid nanovehicles into polymeric films, which will allow controlled release of the nanodroplets with the solubilized drug.

Structural Characterization of Reconstituted Bioactive-Loaded Nanodomains after Embedding in Films Using Electron Paramagnetic Resonance and Self-Diffusion Nuclear Magnetic Resonance Techniques.

Pharmaceutical applications of microemulsions (MEs) as drug delivery vehicles are recently gaining scientific and practical interests. Most MEs are able to solubilize bioactive molecules, but, at present, they cannot guarantee either controlled release of the drugs or significant advantage in the bioavailability of the bioactives. This study proposes to incorporate the modified ME structures, or nanodomains, into a natural polymeric film, to be used as a stable and capacious reservoir of drug-loaded nanodomains.

Serum Chromium Levels Are Higher in Peritoneal Dialysis than in Hemodialysis Patients.

An elevation in serum chromium levels in individuals treated with renal replacement therapy has been previously described, but chromium levels have not been systematically studied in patients treated with different dialysis modalities. The aim of this study was to compare serum chromium levels in patients treated with chronic peritoneal dialysis (PD) and hemodialysis (HD).We studied 169 chronic dialysis patients in a single medical center, of which 148 were treated with HD and 21 with PD.

[Management of patients with malignant obstructive jaundice using bile examination after external biliary drainage].

Aim: To determine optimal time of biliary tract decompression and bile reinfusion into gastrointestinal tract in patients with malignant obstructive jaundice.

Material And Methods: 179 medical records of patients with obstructive jaundice were analyzed in order to identify risk factors of postoperative complications. Prospective trial included bile examination in 34 patients with malignant obstructive jaundice.

[Malignant obstructive jaundice management via external biliary drainage followed by bile examination].

Aim: To determine optimal terms of biliary decompression and bile reinfusion into gastrointestinal tract in patients with malignant obstructive jaundice.

Material And Methods: 179 medical records of patients with obstructive jaundice were analyzed to identify risk factors of postoperative complications. Prospective research included bile examination in 34 patients with malignant obstructive jaundice.

[The importance of sanitary microbiological indices in the evaluation of epidemiological safety of water use in conditions of chemical contamination of water].

The increasing chemicalization of production and life leads to the pollution of water bodies by chemicals, the effect of which on the micro - and macro - organisms is poorly understood. This section of the study in sanitary bacteriology is becoming ever more topical and is an important task of modern hygienic science. One of complicacies of the study of the problem is related with the fact that the presence of only experimental data fails to be sufficient, as the impact of any given chemical substance on different bacteria in the experiment does not mean that under natural conditions, similar results will be obtained.

Cellular mechanism of oral absorption of solidified polymer micelles.

Unlabelled: Oral delivery of poorly soluble and permeable drugs represents a significant challenge in drug development. The oral delivery of drugs remains to be the ultimate route of any drugs. However, in many cases, drugs are not absorbed well in the gastrointestinal tract, or they lose their activity.

Priming by a novel universal influenza vaccine (Multimeric-001)-a gateway for improving immune response in the elderly population.

Background: A new vaccine, "Multimeric-001" (M-001) has been recently developed, containing conserved, common linear influenza epitopes that activate both cellular and humoral arms of the immune system against a wide variety of influenza A and B strains. Apart from its direct action, M-001 is an attractive candidate for priming immune responses to seasonal influenza vaccine for the elderly population. The current clinical study was designed to assess M-001's standalone and priming action in participants over 65 years old.

[Structural and functional changes of external and intracranial arteries in elderly patients of different ethnic groups with ischemic heart disease].

The present article discusses the problem of structural and functional changes in extra-and intracranial arteries in elderly patients with ischemic heart disease (CHD) belonging to different ethnic groups before the upcoming coronary arteriography research and planned operative intervention. We examined 120 elderly patients with ischemic heart disease, including 50 patients of Korean nationality and 70 patients of Slavic ethnicity. Average values of IMT of the right and left CCA patients of South Asian group were significantly lower than those of Slavic ethnicity.

[Surgical treatment and different preoperative preparation of patients with malignant tumors of hepatopancreatoduodenal zone].

Different tactical approaches present to optimize surgical treatment of patients with malignant tumors hepatopancreatoduodenal zone. This research based on diagnosis and results of treatment of tumors of this localization, which included 357 analyzed case histories of patients treated in the Chelyabinsk Regional Hospital from 2010 to 2014. During this study was considered the preoperative preparation of patients with malignant obstructive jaundice genesis, and was assessed its impact on the level of postoperative complications and mortality.

[Determination of ammonia in ambient air by ion chromatography].

The use of the well-known methods for testing the content of ammonia in the air of a populated area at the average daily maximum allowable concentration (0.04 mg/m3) is associated with the high requirement for chemical reagents and with considerable time. Deionized water proposed to be used as an absorption solution in the sample collector with the final ion chromatographic determination of ammonia is an alternative to solving the problem and enables air ammonia to be determined with a sensitivity of 0.

N-acetylcysteine improves residual renal function in peritoneal dialysis patients: a pilot study.

Background: Preservation of peritoneal membrane function and residual renal function is important for the optimal care of peritoneal dialysis patients. N-Acetylcysteine may ameliorate oxidative stress, which is thought to be involved in peritoneal membrane dysfunction. In addition, N-acetylcysteine may have a positive effect on renal function in the setting of nephrotoxic contrast media administration.

Amyloid-beta as a positive endogenous regulator of release probability at hippocampal synapses.

Accumulation of cerebral amyloid-beta peptide (Abeta) is essential for developing synaptic and cognitive deficits in Alzheimer's disease. However, the physiological functions of Abeta, as well as the primary mechanisms that initiate early Abeta-mediated synaptic dysfunctions, remain largely unknown. Here we examine the acute effects of endogenously released Abeta peptides on synaptic transfer at single presynaptic terminals and synaptic connections in rodent hippocampal cultures and slices.

[Problems in the monitoring of bromine-containing substances in the drinking water].

The water concentrations of bromide ions at the level of 0.2 mg/dm3 or higher, which are sufficient for redox reaction of humin compounds under the action of potent oxidizing agents present a potential hazard in the hygienic terms of formation of transformation products, which also agrees with the hygienic standards. The concentration of bromide ions below 0.

[Hygienic assessment of a recirculatory combined air-conditioning extract-and-input system in office building].

The high concentrations of lead were reveled in the air and dust of some premises and on the filters of a combined air-conditioning extract-and-input system in the high-rise office buildings located in the ecologically lead favorable environment. The dust content of lead in some premises on the first floors dust was as high as 200 mg/kg, which was more than 6 times higher than that in the soil at the highway near the office buildings. The use of new technologies and devices for cleaning and optimizing the air in the premises requires analytical studies to assess the quality of the environment, by taking into account the optimal conditions of their operation.

[Electrochemical purification of natural waters from humic compounds].

The article presents a comparative analysis of chemical substances which are formed in natural waters with different concentrations of humic and fulvic acids under the influence of ozone and chlorine, as a result of electrochemical processing. The authors present thermodynamic evaluation of the probability of the formation of transformation products under the influence of oxidizing reagents and during anode oxidation, and demonstrate the effectiveness of electrochemical purification of natural waters from humic compounds by cathode activated carbon. The scheme of a device to perform this process has been developed.

[The dependence of the quantity of silver granules detectable in interphase nuclei after the silver nitrate staining of the chromosomal nucleolus-organizer regions on the conditions for the hypotonic treatment of the cells and the effect on this index of cell treatment by a pharmacological agent causing dissociation of the nucleolar components].

We investigated effects of hypotonic treatment of cultured HL-60 cells and human fibroblasts, and of DRB on the quantity of AgNORs revealed following AgNO3 staining. The average number of grains increases after KCl hypotonic treatment. The lower the concentration of KCl in the solution, the higher the number of silver grains revealed in the nucleoli due to their dissociation into substructures.

[New surgical tactics in the treatment of patients with complicated tuberculosis of the lungs and pleura].

Stepwise surgical tactics by using transsternal transepicardial preocclusion of the main bronchus and lung root vessels, opening of the empyema cavity and pneumotomy has been proposed to treat patients with progressive fibrocavernous tuberculosis complicated by pneumothorax and pleural empyema and extended into the thoracic wall. After 1.5-2 months the main stage of the operation, pleuropulmonectomy, is performed.

[Surgical treatment of cavernous pulmonary tuberculosis].

Analysis is given of the results of a surgical treatment of 75 patients with cavernous pulmonary tuberculosis that was characterized by the prevalence of pathomorphological features (79%) of the process development. It is shown that signs of chemotherapy inefficiency can be established as early as 4-6 months after the treatment of destructive tuberculosis was begun. The distinguishing features of surgical interventions during this period comprise a small volume of resection, minimal intraoperative blood loss and little time spent on the operation.

[Pulmonectomy in tuberculosis surgery].

The results of surgical treatment of 550 patients who were subjected to pulmonectomy for tuberculosis (74.7%) and other respiratory diseases (25.3%) were analysed.