[Polymorphisms of genes of rennin-angiotensine system and their correlation with psychological manifestations of birth stress].

Study of correlation of polymorphisms of genes of the rennin-angiotensine system--insertion-deletion (I/D) polymorphism of the angiotensine-converting enzime (ACE), and the polymorphism of angiotensinogen (AGT), consisting in submission of T into C in the 704 position (M235T)--with various characteristics of psychological functioning and clinical characteristics in women giving birth, was conducted. The group consisted of 56 young female Ss, without chronic diseases in the anamnesis, no complication in the course of pregnancy, birth normal and timely, state of the child normal in all cases. Basing on factor analysis of 7 psychological induces, providing integral assessment of state of the Ss in the course la late pregnancy, giving birth, and the immediately following post partum period, statistically reliable correlation between such first-rate psychological process as creativity, and polymorphism of the gene of angiotensinogene, was demonstrated, as well as difference in distribution of genotypes between the group of women giving birth, and general population.

[Possible correlation of polymorphism of angiotensin-converting enzyme gene with psychological aspects of birth stress].

The paper presents results of a pilot study of genetic correlates of adaptive strategies characteristic for religious and (or) spiritual people in stress, induced by unusual and (or) extreme conditions. Birth stress, experienced by 79 young normal female urban dwellers Ss in the course of late pregnancy, giving birth, and the immediately following period post partum, was chosen as model of stress in general. Their state, as well as the state of the child, was monitored in each case by professional physicians, and assessed according to standard obstetric procedures.

[Effect of ryodipine, fenigidin, verapamil, and manganese ions on the contractile strength and the myometrium potential duration during rhythmic stimulation and at rest].

Action of the calcium channels blocking agents was studied using their strong but reversible concentrations, in different regimens. Riodypine and phenihydine suppressed the contraction strength and shortened the AP duration in the myometrium muscle stripes equally effectively both in resting and under stimulation (0.3 Hz).

[Opioid inhibition of oxytocin release from the posterior lobe of the hypophysis and its significance for obstetrical anesthesiology].

The review of literature presents modern experimental and clinical data on opioid inhibition of oxytocin release from posterior hypophysis lobe during pregnancy and in childbirth. The impact of various narcotic analgesics on oxytocin secretion, myometrium contractility and the condition of the fetus and newborn has been assessed. The data on oxytocin blood plasma level are of importance in the clinical practice for selecting the most suitable anesthesia technique during physiological and pathological labour, especially when modern narcotic analgesics (morphine, promedol, fentanyl, tramadol, etc.

[Prevention of hypotonic hemorrhage in the placental and early puerperal period with prostenone].

To prevent afterbirth and early postpartum hemorrhages the authors used prostenone in 46 (the main group) and oxytocin in 20 females (control group). Intraplacental blood pressure and coagulation parameters were studied. With prostenone, the mean amount of the blood loss turned to be significantly lower (137 +/- 13 ml) than with oxytocin (208 +/- 17 ml).

[Central hemodynamics in women during labor with combined use of prostaglandin E2 and prolonged epidural analgesia].

Changes in central hemodynamics have been studied in 60 women with weak labour efforts treated with prostenon and subject to prolonged epidural analgesia (PEA). It has been established that PEA has a pronounced antihypertensive effect, decreases the heart rate (HR), cardiac index (CI), reserve coefficient (RC) and integral tonic coefficient (ITC) and increases significantly stroke index (SI). Prostenon, having a modulating effect on the cardiovascular system, induces an increase in mean blood pressure (MBP) in hypotensive patients and a decrease in MBP in hypertensive patients, lowers SI and ITC and elevates HR, CI and RC.