Publications by authors named "Abrahao A de Oliveira-Filho"
Article Synopsis
- - Candida albicans is the main cause of oral candidiasis, and its growing resistance to drugs has sparked the search for better antifungal treatments, leading researchers to investigate the effects of (-)-fenchone.
- - The study found that (-)-fenchone is effective against C. albicans, including strains resistant to miconazole, demonstrating strong antifungal properties with a Minimum Inhibitory Concentration (MIC) of 8 μg/mL.
- - Negative effects on the fungus do not stem from cell wall or membrane damage, and although (-)-fenchone has some ability to prevent biofilm formation, it doesn't disrupt existing biofilms; it also showed low toxicity, suggesting it could be a viable treatment
Thiosemicarbazones are well known for their broad spectrum of action, including antitumoral and antiparasitic activities. Thiosemicarbazones work as chelating binders, reacting with metal ions. The objective of this work was to investigate the , , and toxicity and oxidative stress of 2-acetylpyridine-(4)-orthochlorophenyl thiosemicarbazone (TSC01).
View Article and Find Full Text PDFGiardiasis is a neglected disease, and there is a need for new molecules with less side effects and better activity against resistant strains. This work describes the evaluation of the giardicidal activity of thymol derivatives produced from the Morita-Baylis-Hillman reaction. Thymol acrylate was reacted with different aromatic aldehydes, using 1,4-diazabicyclo[2.
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- Chalcones are a group of natural compounds with a specific chemical structure, and this study examines a unique formylated chalcone known for its potential antimicrobial and anticancer properties.
- The research involves isolating the compound 3'-formyl-2',4',6'-trihydroxy-5'-methyldihydrochalcone and providing the first complete NMR data for it, supported by theoretical studies.
- The antibacterial activity of this compound was tested, showing strong effectiveness against certain bacteria.
Sw. (Myrtaceae) is a shrub distributed all over South America and Brazil. Its leaves are traditionally used to treat digestive problems and infections.
View Article and Find Full Text PDFPhenolic compounds, among them isopropyl caffeate, possess antioxidant potential, but not without toxicity and/or adverse effects. The present study aimed to evaluate the antioxidant activity and toxicity of isopropyl caffeate through in silico, and testing. The results showed that isopropyl caffeate presents no significant theoretical risk of toxicity, with likely moderate bioactivity: GPCR binding, ion channel modulation, nuclear receptor binding, and enzyme inhibition.
View Article and Find Full Text PDFInvolvement of Potassium Channels in Vasorelaxant Effect Induced by Valeriana prionophylla Standl. in Rat Mesenteric Artery.
Evid Based Complement Alternat Med
September 2013
Assays in vitro and in vivo were performed on extract from roots and leaves from the Valeriana prionophylla Standl. (VPR and VPF, resp.).
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