A Protocol for Coupling Volumetrically Dynamic In-Vitro Experiments to Numerical Physiology Simulation for a Hybrid Cardiovascular Model.

Objective: The Physiology Simulation Coupled Experiment (PSCOPE) is a hybrid modeling framework that enables a physical fluid experiment to operate in the context of a closed-loop computational simulation of cardiovascular physiology. Previous PSCOPE methods coupled rigid experiments to a lumped parameter network (LPN) of physiology but are incompatible with volumetrically dynamic experiments where fluid volume varies periodically. We address this limitation by introducing a method capable of coupling multi-branch and volumetrically dynamic in-vitro experiments to an LPN.