Publications by authors named "Abraham F L Van Der Spek"
Image-guided biopsy techniques are widely used in clinical practice. Commonly used methods employ either ultrasound (US) or computed tomography (CT) for image guidance. In certain patients, US or CT guidance may be suboptimal, or even impossible, because of artifacts, suboptimal lesion visualization, or both.
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- - Oximes, crucial for treating organophosphate poisoning, have short biological half-lives, but pairing them with macromolecules like dendrimers could enhance their effectiveness.
- - The study explores how oximes (pralidoxime and obidoxime) interact with fifth generation PAMAM dendrimers using various NMR techniques to understand the binding mechanics.
- - Key findings indicate that oximes bind specifically to dendrimers through electrostatic or hydrogen bonding, and that previous binding affects subsequent interactions negatively, which is vital for developing better drug delivery systems.