Increased de novo glutathione production enhances sexual dysfunctions in rats subjected to paradoxical sleep deprivation.

Objective: Poor quality of sexual life has been reported secondary to poor sleep or sleep deprivation. Paradoxical sleep is an integral part of the sleep-wakefulness physiology and prolonged paradoxical sleep deprivation (PSD) may even be fatal. The objective of this investigation was to determine if D-ribose-L-cysteine (RibCys) and zinc (Zn) administration can attenuate the effect of PSD on the sexual function of male rats.

Comparative effects of glibenclamide, metformin and insulin on fetal pancreatic histology and maternal blood glucose in pregnant streptozotocin-induced diabetic rats.

Background: Oral hypoglycemic agents use during pregnancy was assumed to cause fetal macrosomia and skeletal deformities, and maternal complications due to significant transfer across placenta or ineffective control of blood glucose.

Objective: This study investigated effects of insulin, metformin and glibenclamide on maternal blood glucose; and fetal crown-rump length, gross malformation and pancreatic histology in pregnant streptozotocin-induced diabetic rats.

Methods: Twenty-five pregnant rats of groups 1 to 5 as normal and diabetic controls; and diabetic treated with insulin, metformin and glibenclamide were used.

Warfarin-induced vitamin K deficiency affects spermatogenesis in Sprague-Dawley rats.

Vitamin K is present in the testes though its actual function in male reproduction is poorly understood. This study investigated the harmful effect of extrahepatic vitamin K insufficiency on the testicular structure. Sprague-Dawley rats were fed with a diet containing warfarin for 2, 4 and 8 weeks; control animals received a standard diet without warfarin.

Staining characteristics of Lonchocarpus cyanescens leaf extract on the testis of Sprague-Dawley rats.

The use of nonallergic, nontoxic, and eco-friendly natural dyes has become a matter of significant importance due to increased environmental awareness on the need to avoid hazardous synthetic dyes. This study was to determine the staining properties of the dye extract of Lonchocarpus cyanescens on histomorphology of the testis. Freshly cut leaves of L.

Antiovulatory and anti-implantation potential of the methanolic extract of seeds of Abrus precatorius in the rat.

Objective: To investigate the effect of the methanolic extract of seeds of Abrus precatorius on the estrous cycle, ovulation, and implantation of fetuses in Sprague-Dawley rats.

Methods: Cyclic female rats were randomly classified into 4 groups (A through D). Treated rats in group A had daily vaginal smears for a total of 64 consecutive days while being fed A precatorius extract for the first 32 of those days.

Effect of the juice of lime (Citrus aurantifolia) on estrous cycle and ovulation of Sprague-Dawley rats.

Objective: To determine the effect of lime juice on the estrous cycle and ovulation of cyclic female rats.

Methods: Twenty-five adult female Sprague-Dawley rats were used. The study was divided into 2 experiments (I and II).