Synthesis, analgesic and anti-inflammatory activities evaluation of some bi-, tri- and tetracyclic condensed pyrimidines.

Novel series of bicyclic pyrrolo[1,2-c]pyrimidines 3a-g, 5, 6a, b, and 7a, b, tricyclic pyrimido[5,4-e]pyrrolo[1,2-c]pyrimidines 8a-c, 9a-g, 13a-c, 17, 18a, b, 19, 20a,b and 21 and tetracyclic condensed pyrimidines 14, 22 and 23 were synthesized through different chemical reactions. Structures of all synthesized pyrimidine derivatives were supported by spectral and elemental analyses. Analgesic activity evaluation was carried out using acetic acid-induced writhing assay, and all compounds exerted comparable activity to indomethacin.

The effect of gingival retraction procedures on periodontal indices and crevicular fluid cytokine levels: a pilot study.

Purpose: The purpose of this study was to examine the effects of placement of retraction cord subgingivally upon periodontal indices including plaque index (PI), gingival index (GI), pocket depth (PD), bleeding on probing (BOP), and attachment level (AL), as well as gingival crevicular fluid (GCF) and TNF-alpha levels.

Methods: Ten teeth in 6 patients who were periodontally healthy were selected. These teeth had pocket depths of 3 mm or less, no evidence of significant loss of attachment, BOP, or plaque accumulation.

Resistance to crown displacement on a hexagonal implant abutment.

The purpose of this study was to evaluate the resistance and retention of a hexagonal abutment to crown displacement with varying crown heights (10, 12, and 14 mm) and axis of load. Implants were embedded in resin blocks at a 30 degree angle to the vertical. Crowns were made at heights of 10, 12, and 14 mm.

Effect of an antirotation resistance form on screw loosening for single implant-supported crowns.

Statement Of Problem: The gold screw of the single tooth implant-supported restoration has frequently been reported to exhibit the problem of screw loosening.

Purpose: This in vitro study considered an antirotation resistance form with an increased moment arm length as a strategy to increase the net effect of the retaining screw preload.

Material And Methods: Three groups examined included (a) standard abutments (3 mm), (b) modified standard abutments (3 mm) with 4 milled (1 x 1 mm) notches placed equidistant around the periphery, and (c) Estheticone abutments (1 mm).

Detection of prostaglandin E2 and matrix metalloproteinases in implant crevicular fluid.

Studies show that implants exhibiting peri-implantitis contain elevated levels of the cytokine interleukin-1 beta in the gingival crevicular fluid (GCF). This study further evaluated possible mechanisms of osseous loss in peri-implantitis by examining GCF samples for the presence of prostaglandin E2 (PGE2) and proteolytic enzymes, specifically matrix metalloproteinases (MMPs). Results indicated that levels of PGE2 in healthy sites were not significantly different from those at diseased sites.

Detection and measurement of inflammatory cytokines in implant crevicular fluid: a pilot study.

Peri-implantitis has been shown to possess clinical characteristics similar to those of periodontitis. This pilot study was conducted to determine levels of inflammatory cytokines in crevicular fluid from healthy implants and those implants affected by peri-implantitis. Fifty implants from 13 patients were examined.