Quercitrin loaded cyclodextrin based nanosponge as a promising approach for management of lung cancer and COVID-19.

Lung cancer and pandemic acute respiratory disease, COVID-19, are examples of the most worldwide widespread diseases. The aim of the current study is to develop cyclodextrin based nanosponge (CD-NS) for loading the flavonoid drug, quercitrin (QCT). This is to improve its solubility in an attempt to enhance its activity against lung cancer as well as SARS-CoV-2 virus responsible for COVID-19.

Investigation of a new horizon antifungal activity with enhancing the antimicrobial efficacy of ciprofloxacin and its binary mixture via their encapsulation in nanoassemblies: in vitro and in vivo evaluation.

The main goal of this study was to prepare and evaluate nanosponges containing ciprofloxacin (CIP) or its binary mixture with N-acetyl carnosine (NAC). Nanosponges were prepared by ultrasound-assisted synthesis technique using hydroxypropyl βeta-cyclodextrin (HPβ-CD), as the polymer and diphenyl carbonate (DPC) as the crosslinker. Entrapment efficiency (EE%) of CIP or its binary mixture with NAC in nanosponges was deduced spectrophotometrically.

Profile of portal hypertension in hepatosplenic schistosomiasis.

Intrasplenic pressure changes versus ova count in stool of schistosomal portal hypertension in cases of bilharzial hepatic fibrosis were studied before and after 40 mg/kg body weight praziquantel therapy. Praziquantel acts on the vascular level in which it decreases the portal hypertension caused by bilharziasis as detected by decreased size of portal and splenic veins diameter as well as a significant decrease of portal pressure by the decrease of intrasplenic pressure (P less than 0.05).

Alpha-1 antitrypsin and electrolytes in some cases of diarrhoea.

Fifty patients suffering from diarrhea were subjected together with a control group of 20 normal subjects to full clinical examination, stool analysis for parasites and bacteriological examination to identify pathogenic bacteria. Fecal alpha-1-antitrypsin, fecal Na+ and K+ and serum albumin were also estimated. The results showed a significant increase in the fecal alpha-1-antitrypsin and fecal electrolytes in all cases of diarrhea except the simple intestinal bilharzial cases, in which the fecal alpha 1-antitrypsin showed an inverse proportionality with fecal electrolytes.

Latent iron deficiency anaemia in schistosomiasis.

This study was carried on 60 male patients, 20 have simple intestinal mansoniasis, 20 have simple urinary bilharziasis and 20 have hepatosplenic mansoniasis. Latent iron deficiency anaemia, defined as those having normal Hb content (greater than 13 g/dl) and low serum ferritin (less than 15 ng/mL). Such latent anaemia was found in 35% of cases with simple mansoniasis, 20% of cases with simple urinary bilharziasis but not in any case with hepatosplenic mansoniasis.

Some immuno-pathological aspects in bilharzial and amoebic dysentery.

Serum immunoglobulin, secretory IgA in stools and leucocyte migration inhibition test were done for 75 patients suffering from bilharzial and amoebic dysentery as well as 20 normal controls. Sigmoidoscopic examination with immunofluorescent staining of colonic biopsy was done in patients with bilharzial dysentery. Humoral immune response increased significantly as detected by significant increase in serum IgG and IgM.