Publications by authors named "Aboozar Monovarfeshani"
Article Synopsis
- - Primary open-angle glaucoma (POAG) is a major cause of irreversible blindness, with its underlying causes still not fully understood, particularly in patients with normal intraocular pressure (IOP).
- - Genome-wide association studies (GWAS) identified over 240 loci related to POAG and IOP, revealing significant genes involved in pathways such as extracellular matrix organization and cell adhesion.
- - Single-nucleus RNA sequencing in relevant eye tissues highlighted that the identified genes are concentrated in specific cell types within the aqueous outflow pathways and other critical areas, suggesting both IOP-dependent and independent factors in POAG development.
