Pimenov: A potent antifungal medicinal plant.

Background And Purpose: species are well-known antifungal medicinal plants. (Apiaceae family) is a rarely investigated plant endemic to Iran. The present study aimed to assess the antifungal, antibacterial, antioxidant, and cytotoxic activities of root extracts of different plants.

Bioassay-guided isolation and structure elucidation of anti-mycobacterium tuberculosis compounds from Galatella grimmii (Regel & Schmalh.) Sennikov.

Background: Galatella is a genus in the family Asteraceae, represented by 35-45 species. Considering the high effectiveness of the ethyl acetate (EtOAc) fraction of G. grimmii against Mycobacterium tuberculosis (MIC = 0.

Alkaloids in Cancer therapy: Targeting the tumor microenvironment and metastasis signaling pathways.

The use of phytomedicine in cancer therapy is a growing field of research that takes use of the medicinal properties of plant-derived compounds. Under the domain of cancer therapy and management, alkaloids, a prominent group of natural compounds, have showed significant potential. Alkaloids often affect a wide range of essential cellular mechanisms involved in cancer progression.

Abietane-Type Diterpenoids: Insights into Structural Diversity and Therapeutic Potential.

The abietane-type diterpenoids are among the most significant diterpene subsets found in hundreds of plant species belonging to various families. Among which, the members of the genus Salvia and Euphorbia are rich in abietane diterpenoids. Because of the chemical diversity and notable bioactivities, such as anticancer, antiinflammatory, antimicrobial, and antioxidant activities, they are attractive.

Natural-derived acetophenones: chemistry and pharmacological activities.

Acetophenones are naturally occurring phenolic compounds which have found in over 24 plant families and also fungi strains. They are exist in both free or glycosides form in nature. The biological activities of these compounds have been assayed and reported including cytotoxicity, antimicrobial, antimalarial, antioxidant and antityrosinase activities.

C-diterpene alkaloids from lipsky.

The genus is a rich source of diterpene alkaloids. Chemical investigation on an alkaloid rich extract of the whole parts of resulted in the isolation of three C-diterpene alkaloids () and a palmitic acid derivative (). The chemical structures were elucidated by analysis of 1D and 2D-NMR and comparison the data with those reported in the literature.

In vitro antimicrobial and antibiofilm screening of eighteen Iranian medicinal plants.

Background: Natural products are one of the best candidates for controlling drug-resistant pathogens, the advantages of which include low production costs and low side effects. In this study, as potential antimicrobials, the anti-bacterial and antibiofilm activities of several Iranian native medicinal plants were screened.

Methods: The antibacterial/antifungal and anti-biofilm activities of 18 medicinal plants including Reseda lutea L.

Diverse diterpenoids and a triterpenoid from Euphorbia spinidens Bornm. ex Prokh.

Four previously unreported diterpenoids including three ent-atisanes (1-3) and one ent-abietane (4), along with one known linear triterpenoid (5) and five known diterpenoids including four myrsinanes (6-9), and one abietane (10) have been isolated from the roots of Euphorbia spinidens Bornm. ex Prokh. The structures were determined on the basis of extensive spectroscopic analyses including HR-ESI-MS, 1D and 2D NMR and comparison of the data with those reported in the literature.

Antimicrobial and Cytotoxic Naphthoquinones from Microbial Origin: An Updated Review.

Naphthoquinones (NQs) are small molecules bearing two carbonyl groups. They have been the subject of much research due to their significant biological activities such as antiproliferative, antimicrobial, anti-inflammatory, antioxidant, and antimalarial effects. NQs are produced mainly by bacteria, fungi and higher plants.

Neuroprotective Effects of , Sesamin and Sesamolin Against 6-OHDA-induced Apoptosis in PC12 Cells.

Background: L. (sesame) is one of the most widely used herbs in the world. Sesame oil contains lignans such as sesamin and sesamolin, which are known to possess anti-inflammatory, antioxidant, and anti-apoptotic properties.

Efficacy of orally administered montmorillonite in myoglobinuric acute renal failure model in male rats.

Objectives: Acute kidney injury can be associated with serious consequences and therefore early treatment is critical to decreasing mortality and morbidity rate. We evaluated the effect of montmorillonite, the clay with strong cation exchange capacity, on the AKI model in rats.

Materials And Methods: Glycerol (50% solution, 10 ml/kg) was injected in the rat hind limbs to induce AKI.

LC-MS-based metabolite profiling of aqueous extract of L. and its anti-hyperglycemic effect.

Objectives: In this study, to find scientific evidence for the traditional use of as an anti-diabetic remedy, the effects of its aqueous extract on streptozotocin-induced diabetes mellitus in rats were evaluated.

Materials And Methods: Wistar rats were fasted overnight and diabetes mellitus was induced using streptozotocin (50 mg/kg body weight). The rats were randomly and equally divided into four groups (n=5): group I (normoglycaemic control), group II (diabetic rats), group III (diabetic rats treated with 200 mg/kg BW of an aqueous extract of ), group IV (normoglycemic rats treated with 200 mg/kg BW of an aqueous extract of ).

Therapeutic potency of curcumin for allergic diseases: A focus on immunomodulatory actions.

In light of increasing research evidence on the molecular mechanisms of allergic diseases, the crucial roles of innate and acquired immunity in the disease's pathogenesis have been well highlighted. In this respect, much attention has been paid to the modulation of unregulated and unabated inflammatory responses aiming to suppress pathologic immune responses in treating allergic diseases. One of the most important natural compounds with a high potency of immune modulation is curcumin, an active polyphenol compound derived from turmeric, Curcuma longa L.

Cytotoxicity, apoptosis inducing activity and Western blot analysis of tanshinone derivatives from Stachys parviflora on prostate and breast cancer cells.

Cytotoxic activities of methanolic crude extract of Stachys parviflora (Lamiaceae family) and its sub-fractions were primarily evaluated against human breast adenocarcinoma (MCF-7 and MDA-MB-231) and prostate (PC3) cell lines. The methanolic extract exhibited the highest activity, and was chosen for the isolation procedure. Four diterpenoid quinones, namely miltirone [1], tanshinone IIA [2], 1-hydroxy-tanshinone IIA [3], and cryptotanshinone [4] were isolated.

The Regulation, Functions, and Signaling of miR-153 in Neurological Disorders, and Its Potential as a Biomarker and Therapeutic Target.

Treatment of neurological disorders has always been one of the challenges facing scientists due to poor prognosis and symptom overlap, as well as the progress of the disease process. Neurological disorders such as Huntington's, Parkinson's, Alzheimer's diseases, and Amyotrophic Lateral Sclerosis are very debilitating. Therefore, finding a biomarker is essential for early diagnosis and treatment goals.

Structural Diversity of Complex Phloroglucinol Derivatives from Eucalyptus Species.

Several species of the genus Eucalyptus are used in many traditional medicine systems for the treatment of respiratory tract infections, colds, flu, sore throats, and bronchitis. The genus Eucalyptus (Myrtaceae) is a well-known natural source of bioactive phloroglucinols. These polyphenolic compounds bear an aromatic phenyl ring with three hydroxy groups (1,3,5-trihydroxybenzene) which have been exhibiting a variety of biological activities such as antimicrobial, anticancer, anti-allergic, anti-inflammatory, and antioxidant activities.

A review of the protective effects of chlorogenic acid against different chemicals.

Chlorogenic acid (CGA) is a naturally occurring non-flavonoid polyphenol found in green coffee beans, teas, certain fruits, and vegetables, that exerts antiviral, antitumor, antibacterial, and antioxidant effects. Several in vivo and in vitro studies have demonstrated that CGA can protect against toxicities induced by chemicals of different classes such as fungal/bacterial toxins, pharmaceuticals, metals, pesticides, etc., by preservation of cell survival via reducing overproduction of nitric oxide and reactive oxygen species and suppressed pro-apoptotic signaling.

Cytotoxic sesquiterpene lactones and lignans from Bornm (Asteraceae).

Seven sesquiterpene lactones, chlorophyssopifolin E (), aguerin B (), repdiolide triol (), solistitiolide (), aitchisonolide (), sinicin B (), cynaropicrin (), along with four lignans arctigenin (), arctiin (), matairesinol (), and matairesinoside () were isolated for the first time from the aerial parts of Bornm. Among the isolated compounds, aguerin B () showed the most cytotoxic activity against MCF7 cell lines with IC value of 18.9 μM.

Bioactive terpenoids derived from plant endophytic fungi: An updated review (2011-2020).

Plant endophytes have been considered as novel sources of naturally occurring compounds with various biological activities, including cytotoxic, antimicrobial, anti-inflammatory, anticancer, herbicides, antileishmanial and antioxidant. A variety of specialised products, comprising terpenoids, alkaloids, polyketides, phenolic compounds, coumarins, and quinone derivatives have been reported from various strains. An increasing number of products, especially terpenoids, are being isolated from endophytes.

A Review of the Phytochemistry and Antimicrobial Properties of L. and Subspecies.

L. () is an important medicinal herb of the family Lamiaceae. In the current study, we explained the critical evaluation of traditional uses, the phytochemistry and the antimicrobial properties of and its subspecies, with a focus on the mechanisms of actions of the most important phytochemicals from subspecies.

From plants to antimicrobials: Natural products against bacterial membranes.

Bacterial membrane barrier provides a cytoplasmic environment for organelles of bacteria. The membrane is composed of lipid compounds containing phosphatide protein and a minimal amount of sugars, and is responsible for intercellular transfers of chemicals. Several antimicrobials have been found that affect bacterial cytoplasmic membranes.

Quercetin and its role in modulating endoplasmic reticulum stress: A review.

The endoplasmic reticulum (ER) is the place where proteins and lipids are biosynthesized and where transmembrane proteins are folded. Both pathological and physiological situations may disturb the function of the ER, resulting in ER stress. Under stress conditions, the cells initiate a defensive procedure known as the unfolded protein response (UPR).

Protective Effects of Curcumin against Iron-induced Toxicity.

Iron is an essential element in cellular metabolism that participates in many biochemical reactions. Nevertheless, iron overload in the body is the cause of damage in some organs including the liver, glands, brain, heart, gastrointestinal tract and lung. Iron chelation therapy could be considered an effective approach for removing excess iron.

UPLC-PDA-ESI-QTOF-MS/MS and GC-MS analysis of Iranian L.

L. is a significant component in the Iranian food basket. This study aimed to investigate the bioactive compounds and biological activities of different extracts obtained from aerial parts.