Metabolic and Cardiovascular Complications in HIV/HCV-Co-infected Patients.

Purpose Of Review: Fifteen to thirty percent of HIV-infected persons in North America and Europe are co-infected with chronic hepatitis C (HCV). The latter is associated with a significant number of extra-hepatic metabolic complications that could compound HIV-associated increased cardiovascular risk. This article reviews the basic science and epidemiologic and clinical evidence for increased cardio-metabolic risk among HIV/HCV-co-infected patients and discusses potential underlying mechanisms.

Colchicine toxicity precipitated by interaction with sunitinib.

What Is Known And Objective: Colchicine is an anti-inflammatory agent used primarily in treatment of gout and familial Mediterranean fever. Toxicity is uncommon, and depends on dose, hepatic or renal impairment, co-administration with P-glycoprotein or CYP3A4 inhibitors and route of administration. In patients taking p-glycoprotein inhibitors, maximum recommended dose is 0·3 mg per day.

Analgesic and anti-inflammatory effects of the methanol stem bark extract of Prosopis africana.

Prosopis africana (Guill. & Perr.) Taub.

Age related outcome in acute subdural haematoma following traumatic head injury.

Acute subdural haematoma (ASDH) is one of the conditions most strongly associated with severe brain injury. Reports prior to 1980 describe overall mortality rates for acute subdural haematomas (SDH's) ranging from 40% to 90% with poor outcomes observed in all age groups. Recently, improved results have been reported with rapid diagnosis and surgical treatment.

A test of the reliability and validity of a diabetes specific quality of life scale in a Nigerian hospital.

The purpose of this study was to test the reliability of the Well-being and Diabetes Treatment Satisfaction Questionnaires among clinic patients with type 2 diabetes as well as determine the clinical correlates of these measures. A cross-sectional survey was conducted using the Well-being Questionnaire and the Diabetes Treatment Satisfaction Questionnaire. Other demographic and clinical indices of age, sex, body mass index, disease duration and blood glucose levels were also recorded.