Prospective validation of diffusion-weighted MRI as a biomarker of tumor response and oncologic outcomes in head and neck cancer: Results from an observational biomarker pre-qualification study.

Purpose: To determine DWI parameters associated with tumor response and oncologic outcomes in head and neck (HNC) patients treated with radiotherapy (RT).

Methods: HNC patients in a prospective study were included. Patients had MRIs pre-, mid-, and post-RT completion.

Generation of intense and coherent sub-femtosecond X-ray pulses in electron storage rings.

Temporally short X-ray pulses are an indispensable tool for the study of electron transitions close to the Fermi energy and structural changes in molecules undergoing chemical reactions which take place on a time-scale of hundreds of femtoseconds. The time resolution of experiments at 3 generation light sources which produce intense synchrotron radiation is limited fundamentally by the electron-bunch length in the range of tens of picoseconds. Here we propose a new scheme for the generation of intense and coherent sub-femtoseconds soft X-ray pulses in storage rings by applying the Echo-Enabled Harmonic Generation (EEHG) method.

A model describing stable coherent synchrotron radiation in storage rings.

We present a model describing high power stable broadband coherent synchrotron radiation (CSR) in the terahertz frequency region in an electron storage ring. The model includes distortion of bunch shape from the synchrotron radiation (SR), which enhances higher frequency coherent emission, and limits to stable emission due to an instability excited by the SR wakefield. It gives a quantitative explanation of several features of the recent observations of CSR at the BESSY II storage ring.

Brilliant, coherent far-infrared (THz) synchrotron radiation.

A new technology for generating steady state, brilliant, broadband, coherent, far-infrared (FIR) radiation in electron storage rings is presented, suitable for FIR spectroscopy. An FIR power increase of up to 100 000 compared to the normal, incoherent synchrotron radiation in the range of approximately 5 to approximately 40 cm(-1) could be achieved. The source is up to 1000 times more brillant compared to a standard Hg arc lamp.

Steady-state far-infrared coherent synchrotron radiation detected at BESSY II.

At BESSY II it is demonstrated that far-infrared coherent synchrotron radiation (CSR) can be generated by a controlled, steady-state process at storage rings. As an indication for coherent emission, the radiated power grows with the square of the beam current. The spectrum was analyzed by an interferometer in the 1-mm to 0.