miR-1306 induces cell apoptosis by targeting BMPR1B gene in the ovine granulosa cells.

Bone morphogenetic protein receptor type-1B (BMPR1B) is one of the major gene for sheep prolificacy. However, few studies investigated its regulatory region. In this study, we reported that miR-1306 is a direct inhibitor of BMPR1B gene in the ovine granulosa cells (ovine GCs).

Genome-wide identification and characterization of long non-coding RNAs expressed during sheep fetal and postnatal hair follicle development.

Long non-coding RNAs (lncRNAs), >200 nt in length, are transcribed from mammalian genomes. They play important regulatory roles in various biological processes; However, the function and expression profile of lncRNAs involved in the development of hair follicles in the fetus, have been relatively under-explored area. To investigate the specific role of lncRNAs and mRNAs that regulate hair follicle development, we herein performed a comprehensive study on the lncRNA and mRNA expression profiles of sheep at multiple embryonic days (E65, E85, E105, and E135) and six lambs aged one week (D7) and one month (D30) using RNA-seq technology.

Association analysis of polymorphisms in six keratin genes with wool traits in sheep.

Objective: The purpose of this study was to investigate the genetic effects of six keratin () genes on the wool traits of 418 Chinese Merino (Xinjiang type) (CMXT) individuals.

Methods: To explore the effects and association of six genes on sheep wool traits, The polymerase chain reaction-based single-strand conformation polymorphism (PCR-SSCP), DNA sequencing, and the gene pyramiding effect methods were used.

Results: We report 20 mutation sites (single-nucleotide polymorphisms) within the six genes, in which twelve induced silent mutations; five induced missense mutations and resulted in Ile→Thr, Glu→Asp, Gly→Ala, Ala→Ser, Se→His; two were nonsense mutations and one was a same-sense mutation.

WITHDRAWN:Identification of Polymorphisms and Association of Five KAP Genes with Sheep Wool Traits.

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