Induction prednisone dosing for childhood nephrotic syndrome: how low should we go?

Background: Historically, children with nephrotic syndrome (NS) across British Columbia (BC), Canada have been cared for without formal standardization of induction prednisone dosing. We hypothesized that local historical practice variation in induction dosing was wide and that children treated with lower doses had worse relapsing outcomes.

Methods: This retrospective cohort study included 92 NS patients from BC Children's Hospital (1990-2010).

Indications for kidney biopsy in idiopathic childhood nephrotic syndrome.

Background: Most cases of childhood nephrotic syndrome (NS) are due to minimal change disease (MCD), while a minority of children have focal segmental glomerulosclerosis (FSGS) and an unfavorable clinical course, requiring a kidney biopsy to confirm diagnosis. We hypothesized that clinical characteristics at diagnosis and initial response to corticosteroid treatment accurately predict FSGS and can be used to guide consistent practice in the indications for kidney biopsy.

Methods: This was a case control study (1990-2012).