Antimicrobial acrylic materials with in situ generated silver nanoparticles.

Unlabelled: Polymethyl methacrylate (PMMA) is widely used to treat traumatic head injuries (cranioplasty) and orthopedic injuries (bone cement), but there is a problem with implant-centered infections. With organisms such as Acinetobacter baumannii and methicillin-resistant staphylococcus aureus developing resistance to antibiotics, there is a need for novel antimicrobial delivery mechanisms without risk of developing resistant organisms.

Objectives: To develop a novel antimicrobial implant material by generating silver nanoparticles (AgNP) in situ in PMMA.