Publications by authors named "Abish Pius"
Article Synopsis
- Identifying specific subphenotypes of infected patients is crucial for tailored treatment, but the effectiveness of different time series clustering algorithms in this context is not well understood.* -
- The study analyzed data from over 20,000 patients using dynamic time warping and clustering algorithms to identify consistent patterns in vital signs, resulting in four distinct subphenotypes with varying clinical outcomes.* -
- The findings indicate that different clustering methods (DTW-HC, DTW-PAM, and GBTM) yield similar results, highlighting the potential for personalized management strategies based on identified subphenotypes.*
Article Synopsis
- Heterochronic blood exchange (HBE) can restore youthful characteristics to aged tissues, but the specific factors involved are not well understood.
- Research shows that extracellular vesicles (EVs) from young blood are crucial for improving muscle regeneration in older individuals, while aging alters the types and benefits of EVs.
- The study identified that aging affects the genetic composition of EVs, particularly decreasing the levels of the pro-longevity protein α-Klotho, and that delivering EVs can enhance muscle recovery through a Klotho-dependent mechanism.
Aging is accompanied by disrupted information flow, resulting from accumulation of molecular mistakes. These mistakes ultimately give rise to debilitating disorders including skeletal muscle wasting, or sarcopenia. To derive a global metric of growing 'disorderliness' of aging muscle, we employed a statistical physics approach to estimate the state parameter, entropy, as a function of genes associated with hallmarks of aging.
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- The study investigates the role of caspase-1/11 in muscle recovery following ischemia due to peripheral arterial disease and how it interacts with chloroquine (CQ), an autophagy inhibitor.
- Using a mouse model, researchers observed that CQ enhances autophagy markers and caspase-1 expression but negatively impacts muscle recovery in wild-type mice, indicating a reliance on caspase-1/11 for effective recovery.
- Results suggest that the absence of caspase-1/11 in knockout mice leads to improved metabolic responses but reduces overall muscle performance, highlighting a complex relationship between autophagy, inflammation, and muscle healing.
The year 2017 marked the 20th anniversary of the first publication describing Klotho. This single protein was and is remarkable in that its absence in mice conferred an accelerated aging, or progeroid, phenotype with a dramatically shortened life span. On the other hand, genetic overexpression extended both health span and life span by an impressive 30%.
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